HIV integrase, a brief overview from chemistry to therapeutics

被引：237

作者：

Craigie, R ^{[1
]}

机构：

[1] NIDDK, NIH, Mol Biol Lab, Bethesda, MD 20892 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2001年 / 276卷 / 26期

关键词：

D O I：

10.1074/jbc.R100027200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：23213 / 23216

页数：4

共 48 条

[1] Molecular mechanisms in retrovirus DNA integration [J].

Asante-Appiah, E ;

Skalka, AM .

ANTIVIRAL RESEARCH, 1997, 36 (03) :139-156

[2] STRUCTURAL BASIS FOR THE 3'-5' EXONUCLEASE ACTIVITY OF ESCHERICHIA-COLI DNA-POLYMERASE-I - A 2 METAL-ION MECHANISM [J].

BEESE, LS ;

STEITZ, TA .

EMBO JOURNAL, 1991, 10 (01) :25-33

[3] Modeling the late steps in HIV-1 retroviral integrase-catalyzed DNA integration [J].

Brin, E ;

Yi, JZ ;

Skalka, AM ;

Leis, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (50) :39287-39295

[4]

Brown P. O., 1997, P161

[5] HIGH-RESOLUTION STRUCTURE OF THE CATALYTIC DOMAIN OF AVIAN-SARCOMA VIRUS INTEGRASE [J].

BUJACZ, G ;

JASKOLSKI, M ;

ALEXANDRATOS, J ;

WLODAWER, A ;

MERKEL, G ;

KATZ, RA ;

SKALKA, AM .

JOURNAL OF MOLECULAR BIOLOGY, 1995, 253 (02) :333-346

[6] The catalytic domain of avian sarcoma virus integrase: Conformation of the active-site residues in the presence of divalent cations [J].

Bujacz, G ;

Jaskolski, M ;

Alexandratos, J ;

Wlodawer, A ;

Merkel, G ;

Katz, RA ;

Skalka, AM .

STRUCTURE, 1996, 4 (01) :89-96

[7]

BURKE CJ, 1992, J BIOL CHEM, V267, P9639

[8] RIBBON MODELS OF MACROMOLECULES [J].

CARSON, M .

JOURNAL OF MOLECULAR GRAPHICS, 1987, 5 (02) :103-&

[9] Coupled integration of human immunodeficiency virus type 1 cDNA ends by purified integrase in vitro: Stimulation by the viral nucleocapsid protein [J].

Carteau, S ;

Gorelick, RJ ;

Bushman, FD .

JOURNAL OF VIROLOGY, 1999, 73 (08) :6670-6679

[10] Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: A model for viral DNA binding [J].

Chen, JCH ;

Krucinski, J ;

Miercke, LJW ;

Finer-Moore, JS ;

Tang, AH ;

Leavitt, AD ;

Stroud, RM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (15) :8233-8238

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