Anal canal neuroendocrine carcinoma associated with squamous intraepithelial neoplasia: A human papillomavirus 18-related lesion

被引：7

作者：

Ohtomo, Rie ^{[2
]}

Sekine, Shigeki ^{[1
]}

Taniguchi, Hirokazu ^{[2
]}

Tsuda, Hitoshi ^{[2
]}

Moriya, Yoshihiro ^{[3
]}

Kushima, Ryoji ^{[2
]}

机构：

[1] Natl Canc Ctr, Res Inst, Div Pathol, Chuo Ku, Tokyo, Japan

[2] Natl Canc Ctr, Pathol & Clin Lab Div, Tokyo, Japan

[3] Natl Canc Ctr, Colorectal Surg Div, Tokyo, Japan

来源：

PATHOLOGY INTERNATIONAL | 2012年 / 62卷 / 05期

关键词：

anal canal; human papillomavirus; neuroendocrine carcinoma; squamous intraepithelial neoplasia; SMALL-CELL CARCINOMAS; UTERINE CERVIX; EXPRESSION; PROTEINS; ANUS; P16; P53; PCR;

D O I：

10.1111/j.1440-1827.2012.02800.x

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Neuroendocrine carcinoma (NEC) of the anal canal is exceedingly rare and its histogenesis is poorly understood. We present a case of small-cell NEC of the anal canal in a 70-year-old woman. The NEC appeared as a submucosal tumor at the dentate line and was associated with squamous intraepithelial neoplasia (SIN). The NEC was positive for neuroendocrine markers including synaptophysin, chromogranin A and CD56, whereas the SIN component did not express any of these markers. Both components exhibited p16 overexpression. A PCR analysis revealed that both the SIN and NEC components were positive for human papillomavirus (HPV) 18 DNA. Our observations imply that SIN may be a precursor of anal canal NEC and that HPV18 may play an important role in the histogenesis of anal canal NEC, similar to its role in cervical NEC.

引用

页码：356 / 359

页数：4

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