Recent Advances in the Synthesis of 1,3-Azoles

被引：13
作者：
Downer-Riley, Nadale K. [1 ]
Jackson, Yvette A. [1 ]
机构：
[1] Univ West Indies, Dept Chem, Kingston 7, Jamaica
来源：
CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2016年 / 16卷 / 30期
关键词：
1,3-Azoles; Imidazole; Oxazole; Synthesis; Therapeutic agent; Thiazole; ONE-POT SYNTHESIS; 2,4,5-TRISUBSTITUTED OXAZOLES; PRACTICAL SYNTHESIS; DERIVATIVES; INHIBITORS; ACID; IMIDAZOLES; EFFICIENT; CYCLIZATION; THIAZOLES;
D O I：
10.2174/1568026616666160414122349
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The 1,3-azole motif is a common and integral feature of many clinical drugs. Due to their wide-ranging applications, the development of 1,3-azoles as therapeutic agents is an ongoing focus of medicinal chemists. This review highlights the recent approaches towards the assembly of 1,3-oxazole, 1,3-thiazole and 1,3-imidazole motifs.
引用
收藏
页码：3617 / 3626
页数：10
相关论文
共 95 条
[1]   Multicomponent Synthesis of Substituted and Fused-Ring lmidazoles via Phospha-munchnone Cycloaddition [J].
Aly, Sara ;
Romashko, Mikhail ;
Arndtsen, Bruce A. .
JOURNAL OF ORGANIC CHEMISTRY, 2015, 80 (05) :2709-2714
[2]   Oxazole-modified glycopeptides that target arthritis-associated class II MHC Aq and DR4 proteins [J].
Andersson, Ida E. ;
Batsalova, Tsvetelina ;
Dzhambazov, Balik ;
Edvinsson, Lotta ;
Holmdahl, Rikard ;
Kihlberg, Jan ;
Linusson, Anna .
ORGANIC & BIOMOLECULAR CHEMISTRY, 2010, 8 (13) :2931-2940
[3]   Preparation of 2,5-disubstituted oxazoles from N-propargylamides [J].
Arcadi, A ;
Cacchi, S ;
Cascia, L ;
Fabrizi, G ;
Marinelli, F .
ORGANIC LETTERS, 2001, 3 (16) :2501-2504
[4]   Synthesis and Antibacterial Activities of New Metronidazole and Imidazole Derivatives [J].
Atia, Abdul Jabar Kh. .
MOLECULES, 2009, 14 (07) :2431-2446
[5]   New orally active non-peptide fibrinogen receptor (GpIIb-IIIa) antagonists: Identification of ethyl 3-[N-[4-[4-[amino[(ethoxycarbonyl)imino]methyl]phenyl]-1,3-thiazol-2-yl]-N-[1-[(ethoxycarbonyl)methyl]piperid-4-yl]amino]propionate (SR 121787) as a potent and long-acting antithrombotic agent [J].
Badorc, A ;
Bordes, MF ;
deCointet, P ;
Savi, P ;
Bernat, A ;
Lale, A ;
Petitou, M ;
Maffrand, JP ;
Herbert, JM .
JOURNAL OF MEDICINAL CHEMISTRY, 1997, 40 (21) :3393-3401
[6]   Microwave-Assisted Cerium(III)-Promoted Cyclization of Propargyl Amides to Polysubstituted Oxazole Derivatives [J].
Bartoli, Giuseppe ;
Cimarelli, Cristina ;
Cipolletti, Roberto ;
Diomedi, Simone ;
Giovannini, Riccardo ;
Mari, Margherita ;
Marsili, Laura ;
Marcantoni, Enrico .
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2012, 2012 (03) :630-636
[7]   PHENETHYLTHIAZOLETHIOUREA (PETT) COMPOUNDS, A NEW CLASS OF HIV-1 REVERSE-TRANSCRIPTASE INHIBITORS .1. SYNTHESIS AND BASIC STRUCTURE-ACTIVITY RELATIONSHIP STUDIES OF PETT ANALOGS [J].
BELL, FW ;
CANTRELL, AS ;
HOGBERG, M ;
JASKUNAS, SR ;
JOHANSSON, NG ;
JORDAN, CL ;
KINNICK, MD ;
LIND, P ;
MORIN, JM ;
NOREEN, R ;
OBERG, B ;
PALKOWITZ, JA ;
PARRISH, CA ;
PRANC, P ;
SAHLBERG, C ;
TERNANSKY, RJ ;
VASILEFF, RT ;
VRANG, L ;
WEST, SJ ;
ZHANG, H ;
ZHOU, XX .
JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (25) :4929-4936
[8]   Ceftaroline fosamil: a novel broad-spectrum cephalosporin with expanded anti-Gram-positive activity [J].
Biek, Donald ;
Critchley, Ian A. ;
Riccobene, Todd A. ;
Thye, Dirk A. .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2010, 65 :iv9-iv16
[9]   Identification of a dual δ OR antagonist/μ OR agonist as a potential therapeutic for diarrhea-predominant Irritable Bowel Syndrome (IBS-d) [J].
Breslin, Henry J. ;
Diamond, Craig J. ;
Kavash, Robert W. ;
Cai, Chaozhong ;
Dyatkin, Alexey B. ;
Miskowski, Tamara A. ;
Zhang, Sui-Po ;
Wade, Paul R. ;
Hornby, Pamela J. ;
He, Wei .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (14) :4869-4872
[10]   NONSTEROIDAL ANTIINFLAMMATORY AGENTS .1. 2,4-DIPHENYLTHIAZOLE-5-ACETIC ACID AND RELATED COMPOUNDS [J].
BROWN, K ;
CATER, DP ;
CAVALLA, JF ;
GREEN, D ;
NEWBERRY, RA ;
WILSON, AB .
JOURNAL OF MEDICINAL CHEMISTRY, 1974, 17 (11) :1177-1181
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