Immunologic self tolerance maintained by T-cell-mediated control of self-reactive T cells: Implications for autoimmunity and tumor immunity

被引：49

作者：

Sakaguchi, S

Takahashi, T

Yamazaki, S

Kuniyasu, Y

Itoh, M

Sakaguchi, N

Shimizu, J

机构：

[1] Kyoto Univ, Inst Frontier Med Sci, Dept Expt Pathol, Sakyo Ku, Kyoto 6068507, Japan

[2] Tokyo Metropolitan Inst Gerontol, Dept Immunopathol, Tokyo 1730015, Japan

来源：

MICROBES AND INFECTION | 2001年 / 3卷 / 11期

关键词：

self tolerance; immunologic; autoimmunity; tumor immunity; regulatory T cells; CD25;

D O I：

10.1016/S1286-4579(01)01452-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T-cell-mediated dominant control of self-reactive T cells is one mechanism for maintaining immunologic self tolerance. It also hampers the generation of immunity to autologous tumor cells. Abrogation of the control can evoke potent tumor immunity as well as autoimmunity in normal animals. This common regulatory mechanism for autoimmunity and tumor immunity can be exploited to devise a novel immunotherapy against cancer. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

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页码：911 / 918

页数：8

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