Plant-derived exosome-like nanoparticles and their therapeutic activities

被引：185
作者：
Kim, Jisu [1 ,2 ]
Li, Shiyi [1 ,2 ]
Zhang, Shuya [1 ,2 ]
Wang, Jianxin [1 ,2 ,3 ]
机构：
[1] Fudan Univ, Minist Educ, Sch Pharm, Dept Pharmaceut, Shanghai 201203, Peoples R China
[2] Key Lab Smart Drug Delivery, Shanghai 201203, Peoples R China
[3] Fudan Univ, Inst Integrated Chinese & Western Med, Shanghai 200040, Peoples R China
来源：
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2022年 / 17卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Exosomes; Plant-derived exosome-like; nanoparticles; Drug-delivery systems; Nanocarriers; INTRANASALLY ADMINISTERED MEDICATIONS; EXTRACELLULAR VESICLES; DRUG-DELIVERY; MILK EXOSOMES; GINGER; CELLS; BIOGENESIS; INHIBIT; SYSTEMS; CITRUS;
D O I：
10.1016/j.ajps.2021.05.006
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Nanotechnologies have been successfully applied to the treatment of various diseases. Plant-derived exosome-like nanoparticles (PENs) are expected to become effective therapeutic modalities for treating disease or in drug-delivery. PENs are minimally cytotoxic to healthy tissues, with which they show excellent biocompatibility, and are biased towards tumors by targeting specific tissues through special endocytosis mechanisms. Thus, the use of these PENs may expand the scope of drug therapies while reducing the off-target effects. In this review, we summarize the fundamental features and bioactivities of PENs extracted from the grape, grapefruit, ginger, lemon, and broccoli and discuss the applications of these particles as therapeutics and nanocarriers. (C) 2021 Published by Elsevier B.V. on behalf of Shenyang Pharmaceutical University.
引用
收藏
页码：53 / 69
页数：17
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