Long Non-Coding RNA-ATB Attenuates the Angiotensin II- Induced Injury of Vascular Endothelial Cell

Objective. Long noncoding RNA activated by transforming growth factor-II (lncRNA-ATB) has been reported to have critical roles in carcinogenesis and progression of several cancers. However, the expression and biological roles of lncRNA-ATB in cardiovascular disease are still unclear. This study aimed to investigate the role of lncRNA-ATB expression in endothelial cell injury. Materials. Angiotensin II (Ang II)-induced damage to endothelial cells (ECs) plays a crucial role in the research of cardiovascular disease; it is used to treat human umbilical vein endothelial cell (HUVECs) at different concentrations. qRT-PCR is used to identify the expression of lncRNA-ATB in HUVECs. CCK-8 assay and flow cytometry analysis are performed to assess cell viability and apoptosis of HUVECs. Results. Ang II treatment down-regulated the lncRNA-ATB level in HUVECs. Meanwhile, both knockdown of lncRNA-ATB and Ang II treatment impaired the viability, and increased apoptosis rate of cells. Furthermore, overexpression of lncRNA-ATB inhibited cell apoptosis and repaired cell viability in HUVECs. Conclusion. The findings indicated that lncRNA-ATB might be associated with the development of the cardiovascular disease.