Low temperature organocopper-mediated two-component cross coupling/cycloisomerization approach toward N-fused heterocycles

被引:90
作者
Chernyak, Dmitri [1 ]
Gadamsetty, Surendra Babu [1 ]
Gevorgyan, Vladimir [1 ]
机构
[1] Univ Illinois, Dept Chem, Chicago, IL 60607 USA
关键词
D O I
10.1021/ol8008705
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Organocopper reagents smoothly react with heterocyclic propargyl mesylates at low temperature to produce Mused heterocycles. The copper reagent plays a "double duty" in this novel cascade transformation, which proceeds via an S(N)2' substitution followed by a subsequent cycloisomerization step.
引用
收藏
页码:2307 / 2310
页数:4
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