Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Transmission Dynamics and Immune Responses in a Household of Vaccinated Persons

被引：1

作者：

Liu, Jamin ^{[1
,2
]}

Laurie, Matthew T. ^{[2
]}

Rubio, Luis ^{[3
]}

Vazquez, Sara E. ^{[2
,4
]}

Sunshine, Sara ^{[2
]}

Mitchell, Anthea M. ^{[2
,5
]}

Hapte-Selassie, Matthias ^{[2
,5
]}

Mann, Sabrina A. ^{[2
,5
]}

Pilarowski, Genay ^{[6
,7
]}

Black, Douglas ^{[3
]}

Marquez, Carina ^{[3
]}

Rojas, Susana ^{[7
]}

Lionakis, Michail S. ^{[8
]}

Petersen, Maya ^{[9
]}

Whitman, Jeffrey D. ^{[10
]}

Jain, Vivek ^{[3
]}

Anderson, Mark ^{[4
]}

Havlir, Diane ^{[3
]}

DeRisi, Joseph ^{[2
,5
]}

机构：

[1] Univ Calif Berkeley, Univ Calif San Francisco, Grad Program Bioengn, Berkeley, CA 94720 USA

[2] Univ Calif San Francisco, Dept Biochem & Biophys, 1700 4th St, San Francisco, CA 94158 USA

[3] Univ Calif San Francisco, Div HIV Infect Dis & Global Med, San Francisco, CA 94158 USA

[4] Univ Calif San Francisco, Diabet Ctr, Dept Med, San Francisco, CA 94158 USA

[5] Chan Zuckerberg Biohub, San Francisco, CA USA

[6] Publ Hlth Co, Oakland, CA USA

[7] Unidos Salud, San Francisco, CA USA

[8] NIAID, Fungal Pathogenesis Sect, Lab Clin Immunol & Microbiol, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

[9] Univ Calif Berkeley, Div Biostat, Berkeley, CA 94720 USA

[10] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94158 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2022年 / 75卷 / 01期

基金：

美国国家卫生研究院;

关键词：

SARS-CoV-2; antibody neutralization; breakthrough infection; anti; interferon autoantibody; autoimmunity;

D O I：

10.1093/cid/ciac029

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

While SARS-CoV-2 vaccines prevent severe disease effectively, postvaccination "breakthrough" COVID-19 infections and transmission among vaccinated individuals remain ongoing concerns. We present an in-depth characterization of transmission and immunity among vaccinated individuals in a household, revealing complex dynamics and unappreciated comorbidities, including autoimmunity to type 1 interferon in the presumptive index case.

引用

页码：E303 / E306

页数：4

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