Acid-mediated amine exchange of N,N-dimethylformamidines:: Preparation of electron-rich formamidines

被引：11
作者：
Díaz, DD
Lewis, WG
Finn, MG
机构：
[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA
[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA
来源：
SYNLETT | 2005年 / 14期
关键词：
formamidine; acid; amine exchange; imidazole;
D O I：
10.1055/s-2005-872249
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The effect of acid in the amine exchange of N,N-dimethylformamidines has been revisited, allowing the preparation of highly electron-rich compounds that are difficult to obtain under standard conditions. The use of propargylamine as nucleophile led to the formation of substituted imidazoles.
引用
收藏
页码：2214 / 2218
页数：5
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