Distribution of glutathione S-transferase GSTM1 and GSTT1 null phenotypes in Brazilian Amerindians

被引：8

作者：

Klautau-Guimaraes, MD

Hiragi, CD

D'Ascençao, RF

Oliveira, SF

Grisolia, CK

Hatagima, A

Ferrari, I

机构：

[1] Univ Brasilia, Inst Ciencias Biol, Dept Genet & Morfol, BR-70910900 Brasilia, DF, Brazil

[2] Inst Oswaldo Cruz, Dept Genet, BR-20001 Rio De Janeiro, Brazil

来源：

GENETICS AND MOLECULAR BIOLOGY | 2005年 / 28卷 / 01期

关键词：

Munduruku; glutathione S-transferase; Kayabi; null alleles;

D O I：

10.1590/S1415-47572005000100005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The distribution of glutathione S-transferase (GST) GSTM1 and GSTT1 null phenotype frequencies in two Brazilian Amerindian tribes, the Munduruku tribe from Missao Cururu village (79 individuals) and the Kayabi tribe (41 individuals), was analyzed by polymerase chain reaction (PCR) amplification. The GST null phenotype frequencies for the Munduruku sample were 0 % for GSTM1 and 27 % for GSTT1 while for the Kayabi sample the null phenotype frequencies were 27 % for GSTM1 and 29 % for GSTT1. This is the first report of the absence of the GSTM1 null phenotype in any ethnic group.

引用

页码：32 / 35

页数：4

共 22 条

[11] Glutathione S-transferase polymorphisms and their biological consequences [J].