Exercise and colorectal cancer: prevention and molecular mechanisms

被引：27
作者：
Amirsasan, Ramin [1 ]
Akbarzadeh, Maryam [2 ]
Akbarzadeh, Shabnam [1 ]
机构：
[1] Univ Tabriz, Fac Phys Educ & Sport Sci, Dept Exercise Physiol, Tabriz, Iran
[2] Univ Tabriz, Fac Nat Sci, Dept Biol, Tabriz, Iran
来源：
CANCER CELL INTERNATIONAL | 2022年 / 22卷 / 01期
关键词：
Exercise; Physical activity; Colorectal cancer; Prevention; Mechanisms; QUALITY-OF-LIFE; RECREATIONAL PHYSICAL-ACTIVITY; BODY-MASS INDEX; DIETARY CALORIE RESTRICTION; MODERATE-INTENSITY EXERCISE; RANDOMIZED CONTROLLED-TRIAL; ENDOTHELIAL GROWTH-FACTOR; CTNNB1; BETA-CATENIN; COLON-CANCER; AEROBIC EXERCISE;
D O I：
10.1186/s12935-022-02670-3
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Exercise and physical activity have been shown to be strongly associated with a decreased incidence rate of various chronic diseases especially numerous human malignancies. A huge number of clinical trials and meta-analysis have demonstrated that exercise is significantly effective in lowering the risk of colorectal cancer. In addition, it is suggested as an effective therapeutic modality against this cancer type. Therefore, in this review, we will review comprehensibly the effects of exercise in preventing, treating, and alleviating the adverse effects of conventional therapeutic options in colorectal cancer. Moreover, the possible mechanisms underlying the positive effects of exercise and physical activity in colorectal cancer, including regulation of inflammation, apoptosis, growth factor axis, immunity, epigenetic, etc. will be also discussed.
引用
收藏
页数：22
相关论文
共 167 条
[1]   The effects of inpatient exercise therapy on the length of hospital stay in stages I-III colon cancer patients: randomized controlled trial [J].
Ahn, Ki-Yong ;
Hur, Hyuk ;
Kim, Dong-Hyun ;
Min, Jihee ;
Jeong, Duck Hyoun ;
Chu, Sang Hui ;
Lee, Ji Won ;
Ligibel, Jennifer A. ;
Meyerhardt, Jeffrey A. ;
Jones, Lee W. ;
Jeon, Justin Y. ;
Kim, Nam Kyu .
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 2013, 28 (05) :643-651
[2]   Physical activity, mediating factors and risk of colon cancer: insights into adiposity and circulating biomarkers from the EPIC cohort [J].
Aleksandrova, Krasimira ;
Jenab, Mazda ;
Leitzmann, Michael ;
Bueno-de-Mesquita, Bas ;
Kaaks, Rudolf ;
Trichopoulou, Antonia ;
Bamia, Christina ;
Lagiou, Pagona ;
Rinaldi, Sabina ;
Freisling, Heinz ;
Carayol, Marion ;
Pischon, Tobias ;
Drogan, Dagmar ;
Weiderpass, Elisabete ;
Jakszyn, Paula ;
Overvad, Kim ;
Dahm, Christina C. ;
Tjonneland, Anne ;
Bouton-Ruault, Marie-Christine ;
Kuehn, Tilman ;
Peppa, Eleni ;
Valanou, Elissavet ;
La Vecchia, Carlo ;
Palli, Domenico ;
Panico, Salvatore ;
Sacerdote, Carlotta ;
Agnoli, Claudia ;
Tumino, Rosario ;
May, Anne ;
van Vulpen, Jonna ;
Borch, Kristin Benjaminsen ;
Oyeyemi, Sunday Oluwafemi ;
Ramon Quiros, J. ;
Bonet, Catalina ;
Sanchez, Maria-Jose ;
Dorronsoro, Miren ;
Navarro, Carmen ;
Barricarte, Aurelio ;
van Guelpen, Bethany ;
Wennberg, Patrik ;
Key, Timothy J. ;
Khaw, Kay-Tee ;
Wareham, Nicholas ;
Assi, Nada ;
Ward, Heather A. ;
Aune, Dagfinn ;
Riboli, Elio ;
Boeing, Heiner .
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2017, 46 (06) :1823-1835
[3]  
Amemori Sadahiro, 2007, Am J Physiol Gastrointest Liver Physiol, V292, pG923
[4]   The effect of a multidimensional exercise programme on symptoms and side-effects in cancer patients undergoing chemotherapy - The use of semi-structured diaries [J].
Andersen, Christina ;
Adamsen, Lis ;
Moeller, Tom ;
Midtgaard, Julie ;
Quist, Morten ;
Tveteraas, Anders ;
Rorth, Mikael .
EUROPEAN JOURNAL OF ONCOLOGY NURSING, 2006, 10 (04) :247-262
[5]   DNA Methylation and Colorectal Cancer [J].
Ashktorab, Hassan ;
Brim, Hassan .
CURRENT COLORECTAL CANCER REPORTS, 2014, 10 (04) :425-430
[6]  
Askari B., 2017, MED LAB J, V11, P23, DOI [10.29252/mlj.11.6.1, DOI 10.29252/MLJ.11.6.1]
[7]   Impact of physical activity and diet on colorectal cancer survivors' quality of life: a systematic review [J].
Balhareth, Ameera ;
Aldossary, Mohammed Yousef ;
McNamara, Deborah .
WORLD JOURNAL OF SURGICAL ONCOLOGY, 2019, 17 (01)
[8]   Physical Activity, Biomarkers, and Disease Outcomes in Cancer Survivors: A Systematic Review [J].
Ballard-Barbash, Rachel ;
Friedenreich, Christine M. ;
Courneya, Kerry S. ;
Siddiqi, Sameer M. ;
McTiernan, Anne ;
Alfano, Catherine M. .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2012, 104 (11) :815-840
[9]   Effect of exercise on biological pathways in ApcMin/+ mouse intestinal polyps [J].
Baltgalvis, Kristen A. ;
Berger, Franklin G. ;
Pena, Maria Marjorette O. ;
Davis, J. Mark ;
Carson, James A. .
JOURNAL OF APPLIED PHYSIOLOGY, 2008, 104 (04) :1137-1143
[10]   The Interaction of a High-Fat Diet and Regular Moderate Intensity Exercise on Intestinal Polyp Development in ApcMin/+ Mice [J].
Baltgalvis, Kristen A. ;
Berger, Franklin G. ;
Pena, Maria Marjorette O. ;
Davis, J. Mark ;
Carson, James A. .
CANCER PREVENTION RESEARCH, 2009, 2 (07) :641-649
12345678910