Endoscopic ultrasound delivery of an antitumor agent to treat a case of pancreatic cancer

被引：35

作者：

Chang, Kenneth J. ^{[1
]}

Lee, John G. ^{[1
]}

Holcombe, Randall F. ^{[1
]}

Kuo, Jeffrey ^{[1
]}

Muthusamy, Raman ^{[1
]}

Wu, Mark L. ^{[1
]}

机构：

[1] Univ Calif Irvine, Med Ctr, Comprehens Digest Dis Ctr, Orange, CA 92868 USA

来源：

NATURE CLINICAL PRACTICE GASTROENTEROLOGY & HEPATOLOGY | 2008年 / 5卷 / 02期

关键词：

endoscopic ultrasonography; gene therapy; biologic therapy; pancreatic cancer;

D O I：

10.1038/ncpgasthep1033

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background A 72-year-old white male presented to a University Digestive Disease Center with epigastric pain and weight loss. A CT scan suggested that the patient had a mass in his pancreas and he was referred for further diagnostic work-up, staging and treatment. Investigations Endoscopic ultrasound (EUS), EUS-guided fine-needle aspiration Diagnosis Locally advanced, unresectable adenocarcinoma of the pancreas Management Opioid analgesics and EUS-guided celiac neurolysis (transgastric injection of bupivacaine and alcohol on both sides of the celiac artery) for pain relief. Five once-weekly intratumoral injections of TNFerade(TM) (GenVec, Inc., Gaithersburg, MD) by EUS-guided fine needle injection, in combination with chemoradiation (5 FU/XRT), as part of a multicenter clinical trial. Repeat fine-needle aspiration followed by surgical resection of the tumor.

引用

页码：107 / 111

页数：5

共 19 条

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