Switch hitter: Bcl11b in T cells and ILC2s

被引：1

作者：

Harly, Christelle ^{[1
,2
]}

Bhandoola, Avinash ^{[3
]}

机构：

[1] Univ Nantes, Univ Angers, CNRS, INSERM,CRCINA, Nantes, France

[2] LabEx IGO Immunotherapy, Graft, Oncol, Nantes, France

[3] NCI, Lab Genome Integr, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2020年 / 217卷 / 01期

关键词：

D O I：

10.1084/jem.20191739

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this issue of JEM, Hosokawa et al. (https://doi.org/10.1084/jem.20190972) establish that transcription factor Bcl11b regulates almost completely distinct sets of genes in T cell precursors and ILC2s. To understand how this occurs, they identify multiple levels of functional regulation for Bcl11b that are used differently by T cell precursors and ILC2s.

引用

页数：2

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