Switch hitter: Bcl11b in T cells and ILC2s

被引：1

作者：

Harly, Christelle ^{[1
,2
]}

Bhandoola, Avinash ^{[3
]}

机构：

[1] Univ Nantes, Univ Angers, CNRS, INSERM,CRCINA, Nantes, France

[2] LabEx IGO Immunotherapy, Graft, Oncol, Nantes, France

[3] NCI, Lab Genome Integr, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2020年 / 217卷 / 01期

关键词：

D O I：

10.1084/jem.20191739

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this issue of JEM, Hosokawa et al. (https://doi.org/10.1084/jem.20190972) establish that transcription factor Bcl11b regulates almost completely distinct sets of genes in T cell precursors and ILC2s. To understand how this occurs, they identify multiple levels of functional regulation for Bcl11b that are used differently by T cell precursors and ILC2s.

引用

页数：2

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[11] Reprogramming of T Cells to Natural Killer-Like Cells upon Bcl11b Deletion [J].

Li, Peng ;

Burke, Shannon ;

Wang, Juexuan ;

Chen, Xiongfeng ;

Ortiz, Mariaestela ;

Lee, Song-Choon ;

Lu, Dong ;

Campos, Lia ;

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Huntly, Brian ;

Gottgens, Bertie ;

Jenkins, Nancy A. ;

Copeland, Neal G. ;

Colucci, Francesco ;

Liu, Pentao .

SCIENCE, 2010, 329 (5987) :85-89

[12] Double the Double: Revisiting BCL11B's Multimerization [J].

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Schmidt, Christian A. ;

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[13] Oncogenic isoform switch of tumor suppressor BCL11B in adult T-cell leukemia/lymphoma [J].

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Ichikawa, Tomonaga ;

Fauzi, Yanuar Rahmat ;

Kiyonari, Hiroshi ;

Shide, Kotaro ;

Kameda, Takuro ;

Shimoda, Kazuya ;

Ono, Masaya ;

Taki, Tomohiko ;

Taniwaki, Masafumi ;

Futakuchi, Mitsuru ;

Morishita, Kazuhiro .

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[14] The Multifaceted Roles of Bcl11b in Thymic and Peripheral T Cells: Impact on Immune Diseases [J].

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[15] Inhibition of BCL11B expression leads to apoptosis of malignant but not normal mature T cells [J].

Grabarczyk, P. ;

Przybylski, G. K. ;

Depke, M. ;

Voelker, U. ;

Bahr, J. ;

Assmus, K. ;

Broeker, B. M. ;

Walther, R. ;

Schmidt, C. A. .

ONCOGENE, 2007, 26 (26) :3797-3810

[16] Inhibition of BCL11B expression leads to apoptosis of malignant but not normal mature T cells [J].

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G K Przybylski ;

M Depke ;

U Völker ;

J Bahr ;

K Assmus ;

B M Bröker ;

R Walther ;

C A Schmidt .

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[17] Dual role of BCL11B in T-cell malignancies [J].

Przybylski, Grzegorz K. ;

Przybylska, Julia ;

Li, Yangqiu .

BLOOD SCIENCE, 2024, 6 (04) :e00204

[18] Bcl11b: a novel regulator of T-lineage commitment [J].

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Rothenberg, Ellen .

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[19] A hairy situation for ILC2s [J].

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Moro, Kazuyo .

IMMUNITY, 2022, 55 (10) :1756-1758

[20] Down regulation of BCL11B expression inhibits proliferation and induces apoptosis in malignant T cells by BCL11B-935-siRNA [J].

Huang, Xin ;

Chen, Si ;

Shen, Qi ;

Chen, Shaohua ;

Yang, Lijian ;

Grabarczyk, Piotr ;

Przybylski, Grzegorz K. ;

Schmidt, Christian A. ;

Li, Yangqiu .

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