Switch hitter: Bcl11b in T cells and ILC2s

被引：1
|
作者：
Harly, Christelle [1 ,2 ]
Bhandoola, Avinash [3 ]
机构：
[1] Univ Nantes, Univ Angers, CNRS, INSERM,CRCINA, Nantes, France
[2] LabEx IGO Immunotherapy, Graft, Oncol, Nantes, France
[3] NCI, Lab Genome Integr, Ctr Canc Res, NIH, Bethesda, MD 20892 USA
来源：
JOURNAL OF EXPERIMENTAL MEDICINE | 2020年 / 217卷 / 01期
关键词：
D O I：
10.1084/jem.20191739
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In this issue of JEM, Hosokawa et al. (https://doi.org/10.1084/jem.20190972) establish that transcription factor Bcl11b regulates almost completely distinct sets of genes in T cell precursors and ILC2s. To understand how this occurs, they identify multiple levels of functional regulation for Bcl11b that are used differently by T cell precursors and ILC2s.
引用
收藏
页数：2
相关论文
共 50 条
  • [1] The Regulation of Differentiation and Proliferation of the BCL11B Gene In T Cells
    Chen, Si
    Chen, Shao-Hua
    Yang, Lijian
    Zheng, Haitao
    Huang, Xin
    Li, Bo
    Grabarczyk, Piotr
    Przybylski, Grzegorz K.
    Schmidt, Christian A.
    Li, Yangqiu
    BLOOD, 2010, 116 (21) : 1142 - 1142
  • [2] BCL11b调控ILC2机制的研究进展
    虞文坤
    贾海英
    湖北民族学院学报(医学版), 2019, 36 (03) : 64 - 66+70
  • [3] BCL11B knockdown leads to apoptosis of malignant T-cells
    Dittmann, K.
    Grabarczyk, P.
    Dittmann, K.
    Przybylski, G. K.
    Depke, M.
    Voelker, U.
    Bahr, J.
    Assmus, K.
    Broecker, B.
    Walther, R.
    Schmidtz, C. A.
    HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2007, 92 : 53 - 53
  • [4] The role of BCL11B in regulating the proliferation of human naive T cells
    Chen, Si
    Huang, Xin
    Chen, Shaohua
    Yang, Lijian
    Shen, Qi
    Zheng, Haitao
    Li, Bo
    Grabarczyk, Piotr
    Przybylski, Grzegorz K.
    Schmidt, Christian A.
    Li, Yangqiu
    HUMAN IMMUNOLOGY, 2012, 73 (05) : 456 - 464
  • [5] BCL11B Upregulates the Expression of RelA in T Cells Stimulated with Staphylococcal Enterotoxin A
    Yan, Y.
    Wang, S.
    Lin, C.
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2022, 174 (02) : 259 - 264
  • [6] BCL11B Upregulates the Expression of RelA in T Cells Stimulated with Staphylococcal Enterotoxin A
    Y. Yan
    S. Wang
    C. Lin
    Bulletin of Experimental Biology and Medicine, 2022, 174 : 259 - 264
  • [7] Bcl11b is required for differentiation and survival of αβ T lymphocytes
    Wakabayashi, Y
    Watanabe, H
    Inoue, J
    Takeda, N
    Sakata, J
    Mishima, Y
    Hitomi, J
    Yamamoto, T
    Utsuyama, M
    Niwa, O
    Aizawa, S
    Kominami, R
    NATURE IMMUNOLOGY, 2003, 4 (06) : 533 - 539
  • [8] Bcl11b is required for differentiation and survival of αβ T lymphocytes
    Yuichi Wakabayashi
    Hisami Watanabe
    Jun Inoue
    Naoki Takeda
    Jun Sakata
    Yukio Mishima
    Jiro Hitomi
    Takashi Yamamoto
    Masanori Utsuyama
    Ohtsura Niwa
    Shinichi Aizawa
    Ryo Kominami
    Nature Immunology, 2003, 4 : 533 - 539
  • [9] Neuroregulation of ILC2s
    Dempsey, Laurie A.
    NATURE IMMUNOLOGY, 2018, 19 (04) : 316 - 316
  • [10] Neuroregulation of ILC2s
    Laurie A. Dempsey
    Nature Immunology, 2018, 19 : 316 - 316
12345