Metal-Free Method for Direct Synthesis of Functionalized β-Ketoenamines

被引：16

作者：

Zeng, Xiaobao ^{[1
]}

Liu, Chulong ^{[1
]}

Yang, Weiguang ^{[1
]}

Weng, Yunxiang ^{[1
]}

Wang, Xinyan ^{[1
]}

Hu, Yuefei ^{[1
]}

机构：

[1] Tsinghua Univ, Dept Chem, Minist Educ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 84卷 / 06期

关键词：

ALPHA-KETO ACIDS; DECARBOXYLATIVE ALKYNYLATION; POLYSUBSTITUTED PYRROLES; REGIOSPECIFIC SYNTHESIS; BOND FORMATION; ENAMINONES; YNONES; ENAMINOKETONES; CATALYSIS; CLEAVAGE;

D O I：

10.1021/acs.joc.8b03247

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new method for direct synthesis of beta-ketoenamines was developed by a BF3 center dot OEt2-catalyzed cyclization of 1-iodoalkyne and alpha-keto acid followed by an amine-mediated ring-opening in one pot. Its metal-free conditions allowed the easy synthesis of those products bearing the transition metal-sensitive functional groups. Its three-component process achieved wide range of functionalized products.

引用

页码：3656 / 3661

页数：6

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