Biomarkers for small cell lung cancer: Neuroendocrine, epithelial and circulating tumour cells

被引：41

作者：

Stovold, Rachel ^{[1
,4
]}

Blackhall, Fiona ^{[3
]}

Meredith, Suzanne ^{[1
]}

Hou, JianMei ^{[4
]}

Dive, Caroline ^{[4
]}

White, Anne ^{[1
,2
]}

机构：

[1] Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Life Sci, Manchester M13 9PT, Lancs, England

[2] Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Med & Human Sci, Manchester M13 9PT, Lancs, England

[3] Christie NHS Fdn Trust, Manchester M20 4BX, Lancs, England

[4] Paterson Inst Canc Res, Manchester M20 4BX, Lancs, England

来源：

LUNG CANCER | 2012年 / 76卷 / 03期

基金：

英国生物技术与生命科学研究理事会;

关键词：

Small cell lung cancer; Epithelial to mesenchymal transition; Circulating tumour cells; Metastasis; Pro-opiomelanocortin and pro-gastrin releasing peptide; NEURON-SPECIFIC ENOLASE; MOLECULAR PATHOGENESIS; GENE-EXPRESSION; GROWTH-FACTORS; INACTIVATION; DIVERSITY; CARCINOMA; ACTH; NEUROPEPTIDES; TRANSLOCATION;

D O I：

10.1016/j.lungcan.2011.11.015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Small cell lung cancer (SCLC) is characterised by an aggressive clinical course with invariable resistance to chemotherapy despite initially high response rates. There has been little improvement in outcome over the past few decades, with no breakthrough yet in targeted therapies. Recent preclinical data and studies of circulating tumour cells (CFCs) highlight distinct cellular heterogeneity within SCLC. Better understanding of how these phenotypes contribute to metastasis and tumour progression might pave the way for development of more successful targeted therapies. Here we review these studies, their implications for future research and for the incorporation of biomarkers reflecting neuroendocrine, epithelial and mesenchymal phenotypes in clinical studies. (c) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：263 / 268

页数：6

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