Clinical implications of the detection of circulating tumor cells in breast cancer patients

被引：2

作者：

Banys, Malgorzata ^{[1
,2
]}

Hartkopf, Andreas D. ^{[1
]}

Krawczyk, Natalia ^{[1
]}

Becker, Sven ^{[1
]}

Fehm, Tanja

机构：

[1] Univ Tubingen, Dept Obstet & Gynecol, D-72076 Tubingen, Germany

[2] Marienkronkenhous Hamburg, Dept Obstet & Gynecol, D-22087 Hamburg, Germany

来源：

BIOMARKERS IN MEDICINE | 2012年 / 6卷 / 01期

关键词：

biomarker; breast cancer; circulating tumor cell; disseminated tumor cell; prognosis; RNA-POSITIVE CELLS; POLYMERASE-CHAIN-REACTION; TIME RT-PCR; PERIPHERAL-BLOOD; BONE-MARROW; PROGNOSTIC-SIGNIFICANCE; MOLECULAR-DETECTION; SYSTEMIC THERAPY; HER2; STATUS; CYTOKERATIN-19;

D O I：

10.2217/BMM.11.106

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The detection of disseminated tumor cells in bone marrow is a common phenomenon seen in 30-40% of primary breast cancer patients. The presence of disseminated tumor cells at diagnosis as well as the persistence of disseminated tumor cells is strongly associated with poor clinical outcome. Since bone marrow biopsies are not well tolerated by many patients, the evaluation of circulating tumor cells in the blood might become a desired alternative. Circulating tumor cells are routinely detected, depending on stage of the disease and methodology, in 10-80% of breast cancer patients. Recent studies have shown a prognostic potential of circulating tumor cells in both primary and metastatic settings. The evaluation of circulating tumor cells may become one of the crucial markers for prediction of survival and therapy monitoring, and its characterization might enable specific targeting of minimal residual, and metastatic disease.

引用

页码：109 / 118

页数：10

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