Hunting the Chameleon: Structural Conformations of the Intrinsically Disordered Protein Alpha-Synuclein

被引:40
|
作者
Drescher, Malte [1 ]
Huber, Martina [2 ]
Subramaniam, Vinod [1 ,3 ,4 ]
机构
[1] Univ Konstanz, Dept Chem, Konstanz Res Sch Chem Biol & Zukunftskolleg, D-78457 Constance, Germany
[2] Leiden Univ, Dept Mol Phys, NL-2300 RA Leiden, Netherlands
[3] Univ Twente, MESA Inst Nanotechnol, NL-7500 AE Enschede, Netherlands
[4] Univ Twente, MIRA Inst Biomed Technol & Tech Med, NL-7500 AE Enschede, Netherlands
关键词
alpha-synuclein; EPR spectroscopy; FRET; intrinsically disordered proteins; site-directed labeling; ELECTRON-PARAMAGNETIC-RESONANCE; PAIR DISTANCE DISTRIBUTIONS; DISEASE-ASSOCIATED MUTANTS; PARKINSONS-DISEASE; ENERGY-TRANSFER; RESIDUAL STRUCTURE; LINKED MUTATIONS; EXTENDED-HELIX; SPIN LABELS; DYNAMICS;
D O I
10.1002/cbic.201200059
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:761 / 768
页数:8
相关论文
共 50 条
  • [21] Different Conformational Subensembles of the Intrinsically Disordered Protein α-Synuclein in Cells
    Fakhree, Mohammad A. A.
    Nolten, Ine Segers
    Blum, Christian
    Claessens, Mireille M. A. E.
    JOURNAL OF PHYSICAL CHEMISTRY LETTERS, 2018, 9 (06): : 1249 - 1253
  • [22] Structural Proteomics Methods to Interrogate the Conformations and Dynamics of Intrinsically Disordered Proteins
    Beveridge, Rebecca
    Calabrese, Antonio N.
    FRONTIERS IN CHEMISTRY, 2021, 9
  • [23] A structural entropy index to analyse local conformations in intrinsically disordered proteins
    Akhila, Melarkode Vattekatte
    Narwani, Tarun Jairaj
    Floch, Aline
    Maljkovic, Mirjana
    Bisoo, Soubika
    Shinada, Nicolas K.
    Kranjc, Agata
    Gelly, Jean-Christophe
    Srinivasan, Narayanaswamy
    Mitic, Nenad
    de Brevern, Alexandre G.
    JOURNAL OF STRUCTURAL BIOLOGY, 2020, 210 (01)
  • [24] Structural and functional characterization of two alpha-synuclein strains
    Bousset, Luc
    Pieri, Laura
    Ruiz-Arlandis, Gemma
    Gath, Julia
    Jensen, Poul Henning
    Habenstein, Birgit
    Madiona, Karine
    Olieric, Vincent
    Boeckmann, Anja
    Meier, Beat H.
    Melki, Ronald
    NATURE COMMUNICATIONS, 2013, 4
  • [25] Structural and functional characterization of two alpha-synuclein strains
    Luc Bousset
    Laura Pieri
    Gemma Ruiz-Arlandis
    Julia Gath
    Poul Henning Jensen
    Birgit Habenstein
    Karine Madiona
    Vincent Olieric
    Anja Böckmann
    Beat H. Meier
    Ronald Melki
    Nature Communications, 4
  • [26] Synergy between the structured and disordered regions of alpha-synuclein in membrane remodeling
    Johnson, David H.
    Zeno, Wade F.
    BIOPHYSICAL JOURNAL, 2024, 123 (03) : 74A - 74A
  • [27] Structural and Biophysical Characterization of Stable Alpha-Synuclein Oligomers
    Vaikath, Nishant
    Sudhakaran, Indulekha
    Abdi, Ilham
    Gupta, Vijay
    Majbour, Nour
    Ghanem, Simona
    Abdesselem, Houari
    Vekrellis, Kostas
    El-Agnaf, Omar
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (23)
  • [28] Ligand Binding on Intrinsic Disordered Proteins: Focus on Human Alpha-Synuclein
    Rossetti, Giulia
    BIOPHYSICAL JOURNAL, 2013, 104 (02) : 379A - 379A
  • [29] A protein-chameleon:: Conformational plasticity of α-synuclein, a disordered protein involved in neurodegenerative disorders
    Uversky, VN
    JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2003, 21 (02): : 211 - 234
  • [30] Modeling synucleinopathies: intracellular delivery of alpha-synuclein oligomers via protein transfection results in intracellular alpha-synuclein inclusions
    Martone, R.
    Meehan, J.
    Xu, J. Z.
    Mercado, M. L.
    Staal, R.
    Hubbell, A.
    Kubek, K.
    Nawoschik, S.
    Das, I.
    Shih, H.
    Dunlop, J.
    Pangalos, M.
    Reinhart, P.
    PARKINSONISM & RELATED DISORDERS, 2009, 15 : S149 - S149