Current status of immunosuppressive agents for solid organ transplantation in children

被引：30

作者：

Coelho, Tracy ^{[1
]}

Tredger, Michael ^{[2
]}

Dhawan, Anil ^{[1
]}

机构：

[1] Kings Coll London, Paediat Liver GI & Nutr Ctr, Univ London Kings Coll Hosp, Sch Med, London SE5 9RS, England

[2] Kings Coll Hosp, Inst Liver Studies, London SE5 8RX, England

来源：

PEDIATRIC TRANSPLANTATION | 2012年 / 16卷 / 02期

关键词：

transplantation; immunosuppression; allograft; rejection; PEDIATRIC LIVER-TRANSPLANTATION; RENAL-ALLOGRAFT RECIPIENTS; OKT3; MONOCLONAL-ANTIBODY; DOSE CYCLOSPORINE MONOTHERAPY; RANDOMIZED CLINICAL-TRIAL; SINGLE-CENTER EXPERIENCE; MYCOPHENOLATE-MOFETIL; ACUTE REJECTION; INDUCTION THERAPY; KIDNEY-TRANSPLANTATION;

D O I：

10.1111/j.1399-3046.2012.01644.x

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Immunosuppression after organ transplantation is complex and ever evolving. Over the past two decades, newer immunosuppressive agents have been introduced with an aim to provide better patient and graft survival. Improved therapeutic strategies have been developed offering the option to use combinations of drugs with non-overlapping toxicities. There are, however, only a few clinical studies with robust data to rationalize the use of these agents in children. This review will discuss the newer immunosuppressive agents used for solid organ transplant, their current status in post-transplant management and prevention of allograft rejection.

引用

页码：106 / 122

页数：17

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