Coibacins A-D, Antileishmanial Marine Cyanobacterial Polyketides with Intriguing Biosynthetic Origins

被引：46

作者：

Balunas, Marcy J. ^{[1
,2
,3
,4
]}

Grosso, Manuel F. ^{[4
]}

Villa, Francisco A. ^{[1
,2
]}

Engene, Niclas ^{[1
,2
]}

McPhail, Kerry L. ^{[5
]}

Tidgewell, Kevin ^{[1
,2
]}

Pineda, Laura M. ^{[4
]}

Gerwick, Lena ^{[1
,2
]}

Spadafora, Carmenza ^{[4
]}

Kyle, Dennis E. ^{[6
]}

Gerwick, William H. ^{[1
,2
,3
]}

机构：

[1] Univ Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA

[3] Smithsonian Trop Res Inst, Panama City, Panama

[4] Inst Invest Cient & Serv Alta Technol, Panama City, Panama

[5] Oregon State Univ, Coll Pharm, Corvallis, OR 97331 USA

[6] Univ S Florida, Coll Publ Hlth, Dept Global Hlth, Tampa, FL 33612 USA

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 15期

关键词：

D O I：

10.1021/ol301607q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Four unsaturated polyketide lactone derivatives, coibacins A-D, were isolated from a Panamanian marine cyanobacterium, cf. Oscillatorla sp. The two different types of termini observed in these co-occurring metabolites, either a methyl cyclopropyl ring as seen in curacin A or a methyl vinyl chloride similar to that observed in the jamaicamides, suggest an intriguing flexibility in the "beta branch" forming biosynthetic process. The coibacins possess selective antileishmanial activity as well as potent anti-inflammatory activity.

引用

页码：3878 / 3881

页数：4

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