Anti-Inflammatory and Anticoagulative Effects of Paeonol on LPS-Induced Acute Lung Injury in Rats

被引：69

作者：

Fu, Pin-Kuei ^{[2
,3
,4
]}

Wu, Chieh-Liang ^{[2
,4
,5
]}

Tsai, Tung-Hu ^{[6
]}

Hsieh, Ching-Liang ^{[1
,7
,8
]}

机构：

[1] China Med Univ Hosp, Dept Chinese Med, Taichung 40402, Taiwan

[2] Taichung Vet Gen Hosp, Div Crit Care & Resp Therapy, Dept Internal Med, Taichung 407, Taiwan

[3] China Med Univ, Coll Chinese Med, Grad Inst Chinese Med Sci, Taichung 40402, Taiwan

[4] Taichung Vet Gen Hosp, Div Chest Med, Dept Internal Med, Chiayi Branch, Chiayi 600, Taiwan

[5] China Med Univ, Coll Med, Sch Med, Taichung 40402, Taiwan

[6] Natl Yang Ming Univ, Inst Tradit Med, Sch Med, Taipei 112, Taiwan

[7] China Med Univ, Coll Chinese Med, Grad Inst Acupuncture Sci, Taichung 40402, Taiwan

[8] China Med Univ, Acupuncture Res Ctr, Taichung 40402, Taiwan

来源：

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2012年 / 2012卷

关键词：

NITRIC-OXIDE SYNTHASE; LOCAL ACTIVATION; ANIMAL-MODELS; VIIA PATHWAY; PROTEIN-C; KAPPA-B; COAGULATION; ENDOTOXIN; INHIBITION; FIBRINOLYSIS;

D O I：

10.1155/2012/837513

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Paeonol is an active component of Moutan Cortex Radicis and is widely used as an analgesic, antipyretic, and anti-inflammatory agent in traditional Chinese medicine. We wanted to determine the role of paeonol in treating adult respiratory distress syndrome (ARDS). We established an acute lung injury (ALI) model in Sprague-Dawley rats, which was similar to ARDS in humans, using intratracheal administration of lipopolysaccharide (LPS). The intraperitoneal administration of paeonol successfully reduced histopathological scores and attenuated myeloperoxidase-reactive cells as an index of polymorphonuclear neutrophils infiltration and also reduces inducible nitric oxide synthase expression in the lung tissue, at 16 h after LPS administration. In addition, paeonol reduced proinflammatory cytokines in bronchoalveolar lavage fluid, including tumor-necrosis factor-alpha, interleukin-1 beta, interleukin-6, and plasminogen-activated inhibition factor-1. These results indicated that paeonol successfully attenuates inflammatory and coagulation reactions to protect against ALI.

引用

页数：12

共 52 条

[1] Neutrophils and acute lung injury [J].