Circulating and ex vivo production of pyrogenic cytokines and interleukin-1 receptor antagonist in 123 patients with fever of unknown origin

被引：10

作者：

deKleijn, EMHA ^{[1
]}

Drenth, JPH ^{[1
]}

Pesman, GJ ^{[1
]}

vanDruten, H ^{[1
]}

Demacker, PNM ^{[1
]}

vanderMeer, JWM ^{[1
]}

deKleijn, EMHA ^{[1
]}

vanderMeer, JWM ^{[1
]}

Demacker, P ^{[1
]}

Corstens, FHM ^{[1
]}

Meinders, AE ^{[1
]}

Pauwels, EKJ ^{[1
]}

Vandenbroucke, JP ^{[1
]}

vanEer, M ^{[1
]}

Kreeftenberg, HG ^{[1
]}

Piers, DR ^{[1
]}

Speelman, P ^{[1
]}

vanRoyen, EA ^{[1
]}

Claessen, F ^{[1
]}

Teule, GJJ ^{[1
]}

deMarie, S ^{[1
]}

Krenning, EP ^{[1
]}

Schneider, M ^{[1
]}

Hoepelman, A ^{[1
]}

vanRijk, PP ^{[1
]}

vanderGeest, S ^{[1
]}

Heidendal, GAK ^{[1
]}

机构：

[1] UNIV NIJMEGEN ST RADBOUD HOSP,DEPT MED STAT,NL-6500 HB NIJMEGEN,NETHERLANDS

来源：

JOURNAL OF INFECTIOUS DISEASES | 1997年 / 175卷 / 01期

关键词：

D O I：

10.1093/infdis/175.1.191

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Circulating and ex vivo production of interleukin (IL)-1 beta, tumor necrosis factor (TNF)-alpha, IL-6, and IL-1 receptor antagonist (ra) and the diagnostic utility of these cytokines were studied in 123 patients with fever of unknown origin (FUO). Diagnoses were infections, 28; neoplasms, 14; noninfectious inflammatory diseases (NIID), 32; miscellaneous diseases, 10; and none made, 39. IL-1 beta, IL-6, and IL-1ra concentrations were higher in patients with infections, neoplasms, and NIID than in healthy controls. Patients with infections had higher concentrations of TNF-alpha than controls. The ex vivo production of IL-1 beta and IL-1ra in all patients with FUO did not differ from that in controls; however, production of TNF-alpha was lower in patients with neoplasms and NIID, and IL-6 production was lower in patients with neoplasms. Thirty-five patients with fever did not have elevated cytokines. Although some significant differences were found among the diagnostic subgroups, there was wide variation. Thus, measurement of these cytokines does not aid in the diagnosis of FUO.

引用

页码：191 / 195

页数：5

共 13 条

[1] CYTOKINE PROFILE IN SYSTEMIC LUPUS-ERYTHEMATOSUS, RHEUMATOID-ARTHRITIS, AND OTHER RHEUMATIC DISEASES [J].

ALJANADI, M ;

ALBALLA, S ;

ALDALAAN, A ;

RAZIUDDIN, S .

JOURNAL OF CLINICAL IMMUNOLOGY, 1993, 13 (01) :58-67

[2]

CORTES LFL, 1993, CLIN INFECT DIS, V166, P534

[3]

DINARELLO CA, 1991, BLOOD, V77, P1627

[4]

DINARELLO CA, 1988, REV INFECT DIS, V10, P168

[5] ENDURANCE RUN INCREASES CIRCULATING IL-6 AND IL-1RA BUT DOWN-REGULATES EX-VIVO TNF-ALPHA AND IL-1-BETA PRODUCTION [J].

DRENTH, JPH ;

VANUUM, SHM ;

VANDEUREN, M ;

PESMAN, GJ ;

VANDERVENJONGEKRIJG, J ;

VANDERMEER, JWM .

JOURNAL OF APPLIED PHYSIOLOGY, 1995, 79 (05) :1497-1503

[6] PROLONGED ELEVATION OF INTERLEUKIN-8 AND INTERLEUKIN-6 CONCENTRATIONS IN PLASMA AND OF LEUKOCYTE INTERLEUKIN-8 MESSENGER-RNA LEVELS DURING SEPTICEMIC AND LOCALIZED PSEUDOMONAS-PSEUDOMALLEI INFECTION [J].

FRIEDLAND, JS ;

SUPUTTAMONGKOL, Y ;

REMICK, DG ;

CHAOWAGUL, W ;

STRIETER, RM ;

KUNKEL, SL ;

WHITE, NJ ;

GRIFFIN, GE .

INFECTION AND IMMUNITY, 1992, 60 (06) :2402-2408

[7]

GAUSE A, 1991, LYMPHOKINE CYTOK RES, V11, P109

[8] SENSITIVE ELISA FOR INTERLEUKIN-6 - DETECTION OF IL-6 IN BIOLOGICAL-FLUIDS - SYNOVIAL-FLUIDS AND SERA [J].

HELLE, M ;

BOEIJE, L ;

DEGROOT, E ;

DEVOS, A ;

AARDEN, L .

JOURNAL OF IMMUNOLOGICAL METHODS, 1991, 138 (01) :47-56

[9] PATTERNS OF PROINFLAMMATORY CYTOKINES AND INHIBITORS DURING TYPHOID-FEVER [J].

KEUTER, M ;

DHARMANA, E ;

GASEM, MH ;

VANDERVENJONGEKRIJG, J ;

DJOKOMOELJANTO, R ;

DOLMANS, WMV ;

DEMACKER, P ;

SAUERWEIN, R ;

GALLATI, H ;

VANDERMEER, JWM .

JOURNAL OF INFECTIOUS DISEASES, 1994, 169 (06) :1306-1311

[10]

NIELSEN OH, 1993, DAN MED BULL, V40, P247

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