Current concepts in osteolysis

被引：85

作者：

Ollivere, B. ^{[1
]}

Wimhurst, J. A.

Clark, I. M.

Donell, S. T.

机构：

[1] Norfolk & Norwich Univ Hosp, Norwich NR4 7UY, Norfolk, England

来源：

JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME | 2012年 / 94B卷 / 01期

关键词：

TOTAL HIP-ARTHROPLASTY; NECROSIS-FACTOR-ALPHA; FRICTIONAL TORQUE ARTHROPLASTY; WEAR DEBRIS; OSTEOCLAST DIFFERENTIATION; BIPOLAR HEMIARTHROPLASTY; CHITOTRIOSIDASE ACTIVITY; DEVELOPMENTAL DYSPLASIA; RHEUMATOID-ARTHRITIS; PARTICULATE DEBRIS;

D O I：

10.1302/0301-620X.94B1.28047

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

The most frequent cause of failure after total hip replacement in all reported arthroplasty registries is peri-prosthetic osteolysis. Osteolysis is an active biological process initiated in response to wear debris. The eventual response to this process is the activation of macrophages and loss of bone. Activation of macrophages initiates a complex biological cascade resulting in the final common pathway of an increase in osteolytic activity. The biological initiators, mechanisms for and regulation of this process are beginning to be understood. This article explores current concepts in the causes of, and underlying biological mechanism resulting in peri-prosthetic osteolysis, reviewing the current basic science and clinical literature surrounding the topic.

引用

页码：10 / 15

页数：6

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