A new triterpene saponin from Androsace integra

被引：8
|
作者：
Dong, Weiwei [1 ,3 ,4 ]
Liu, Xin [2 ]
Li, Xiaobo [1 ]
Yang, Dajian [4 ]
Ding, Lisheng [2 ]
机构：
[1] Shanghai Jiao Tong Univ, Shanghai 200240, Peoples R China
[2] Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China
[3] Shenzhen Virtual Univ Pk Postdoc Stn, Shenzhen 518057, Peoples R China
[4] State Key Lab Chinese Med & Mol Pharmacol, Shenzhen 518057, Peoples R China
来源：
FITOTERAPIA | 2011年 / 82卷 / 05期
关键词：
Androsace integra; Primulaceae; Triterpene saponin; Cytotoxic effect; HUMAN HEPATOMA-CELLS; ARDISIA-CRENATA; UMBELLATA;
D O I：
10.1016/j.fitote.2011.04.001
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new triterpene saponin, androsacin (1), along with two known compounds, ardisiacrispin A (2) and saxifragifolin A (3), were isolated from the whole plants of Androsace integra. The chemical structure of the new compound was elucidated as 3 beta-O-{beta-D-glucopyranosyl-(1 -> 4)-O-beta-D-xylopyranosyl-(1 -> 2)-O-beta-D-glucopyranosyl-(1 -> 4)-[O-beta-D-glucopyranosyl-(1 -> 2))-alpha-L-arabinopyranosyl}-16 alpha-hydroxy-13 beta,28-epoxy-olean-30-al on the basis of spectral evidence. Ardisiacrispin A (2) was cytotoxic toward HepG2 cancer cell with the GI(50) value of 1.56 mu M. Crown Copyright (C) 2011 Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：782 / 785
页数：4
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