Role of arachidonic acid lipoxygenase pathway in Asthma

被引：17
|
作者：
Luo, Yacan [1 ]
Jin, Minli [1 ]
Lou, Lejing [1 ]
Yang, Song [1 ]
Li, Chengye [1 ]
Li, Xi [2 ]
Zhou, Meixi [1 ]
Cai, Chang [1 ]
机构：
[1] Wenzhou Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 1, Wenzhou 325000, Zhejiang, Peoples R China
[2] Wenzhou Med Univ, Affiliated Kangning Hosp, Wenzhou, Peoples R China
来源：
PROSTAGLANDINS & OTHER LIPID MEDIATORS | 2022年 / 158卷
基金：
中国国家自然科学基金;
关键词：
Lipoxygenase; Arachidonic acid; Asthma; Airway inflammation; LIPOXIN A(4); 5-LIPOXYGENASE; RECEPTOR; GENERATION; PHOSPHORYLATION; LEUKOTRIENES; INFLAMMATION; MONTELUKAST; INHIBITION; EXPRESSION;
D O I：
10.1016/j.prostaglandins.2021.106609
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The arachidonic acid (AA) metabolism pathways play a key role in immunological response and inflammation diseases, such as asthma, etc. AA in cell membranes can be metabolized by lipoxygenases (LOXs) to a screen of bioactive substances that include leukotrienes (LTs), lipoxins (LXs), and eicosatetraenoic acids (ETEs), which are considered closely related to the pathophysiology of respiratory allergic disease. Studies also verified that drugs regulating AA LOXs pathway have better rehabilitative intervention for asthma. This review aims to summarize the physiological and pathophysiological importance of AA LOXs metabolism pathways in asthma and to discuss its prospects of therapeutic strategies.
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页数：7
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