Enantioselective Synthesis of (+)-N-(Desmethyl)dysibetaine CPb

被引：3

作者：

Tanaka, Kento ^{[1
]}

Sakai, Michihiro ^{[1
]}

Takamizawa, Satoshi ^{[1
]}

Oikawa, Masato ^{[1
]}

机构：

[1] Yokohama City Univ, Kanazawa Ku, Yokohama, Kanagawa 2360027, Japan

来源：

CHEMISTRY LETTERS | 2015年 / 44卷 / 03期

关键词：

SPONGE DYSIDEA-HERBACEA; EXCITATORY AMINO-ACID; MARINE SPONGE; DYSIHERBAINE;

D O I：

10.1246/cl.141049

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthetic efforts to dysibetaine CPb, isolated from Micronesian marine sponge, amenable to analog synthesis are reported. Cyclopropane was constructed by a sulfonium ylide-mediated reaction and enantioselective desymmetrization was performed by methanolysis mediated by a quinine derivative. (+)-N-(Desmethyl)dysibetaine CPb was finally synthesized in 0.37% yield in total 14 steps. This is the first synthesis of the dysibetaine CPb analog.

引用

页码：253 / 255

页数：3

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