Phosphoryl-EZH-ion

被引：25

作者：

Caretti, Giuseppina ^{[2
]}

Palacios, Daniela ^{[3
,4
]}

Sartorelli, Vittorio ^{[1
]}

Puri, Pier Lorenzo ^{[3
,4
,5
]}

机构：

[1] NIAMS, Lab Muscle Stem Cells & Gene Regulat, NIH, Bethesda, MD 20892 USA

[2] Univ Milan, Dept Biomol Sci & Biotechnol, I-20133 Milan, Italy

[3] IRCCS Fdn Santa Lucia, DTI, I-00143 Rome, Italy

[4] European Brain Res Inst, I-00143 Rome, Italy

[5] Sanford Burnham Inst Med Res, La Jolla, CA 92037 USA

来源：

CELL STEM CELL | 2011年 / 8卷 / 03期

关键词：

SUPPRESSES METHYLATION; SKELETAL-MUSCLE; GENE-EXPRESSION; PROTEIN EZH2; POLYCOMB; CHROMATIN; DIFFERENTIATION; KINASES; ATLAS; CELLS;

D O I：

10.1016/j.stem.2011.02.012

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Polycomb group (PcG) proteins regulate gene expression in embryonic and adult stem cells, but the mechanisms responsible for PcG gene targeting and regulation remain largely unknown. Recent evidence shows that EZH2, the enzymatic subunit of Polycomb Repressive Complex 2 (PRC2), is a nuclear phosphoprotein linking cell-cycle-intrinsic or extracellular signals to specific epigenetic signatures.

引用

页码：262 / 265

页数：4

共 24 条

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