Synthesis, characterisation and antimicrobial activity of (5-bromo-5-nitro-2-oxido-1,3,2-dioxaphosphinan-2-yl) amino acid esters

被引：1

作者：

Santhipriya, Pemmasani ^{[2
]}

Rani, Chinthaparthi Radha ^{[1
]}

Reddy, Nandanur Jagannadha ^{[2
]}

Sundar, Chereddy Syama ^{[1
]}

Reddy, Cirandur Suresh ^{[1
]}

机构：

[1] Sri Venkateswara Univ, Dept Chem, Tirupati 517502, Andhra Pradesh, India

[2] SGHR & MCMR Degree Coll, Dept Chem, Guntur, India

来源：

JOURNAL OF THE SERBIAN CHEMICAL SOCIETY | 2011年 / 76卷 / 05期

关键词：

dioxaphosphinane; 2-bromo-2-nitropropane-1,3-diol; amino acid ester hydrochlorides; antibacterial activity; antifungal activity; DERIVATIVES; CONFIGURATION; PHOSPHORUS;

D O I：

10.2298/JSC100520059S

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Synthesis of a new series of (5-bromo-5-nitro-2-oxido-1,3,2-dioxaphosphinan-2-yl)amino acid esters (3a-l) was accomplished via a two step process, which involves the prior preparation of the monochloride intermediate (2) and its subsequent reaction with the amino acid esters in dry tetrahydrofuran in the presence of triethylamine at reflux temperature. The title compounds (3a-l) structures were established by analytical, IR, (1)H-, (13)C- and (31)P-NMR, and mass spectral data. They exhibited significant antibacterial and antifungal activity.

引用

页码：693 / 698

页数：6

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