Long non-coding RNA FOXD2-AS1 plays an oncogenic role in hepatocellular carcinoma by targeting miR-206

被引：39
|
作者：
Chang, Yuanhong [1 ,2 ]
Zhang, Jie [3 ]
Zhou, Cancan [4 ]
Qiu, Guanglin [5 ]
Wang, Guanghui [5 ]
Wang, Shufeng [5 ]
Chang, Xinming [1 ]
Li, Xuqi [5 ]
Fan, Lin [5 ]
机构：
[1] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Gastroenterol, Xian 710061, Shaanxi, Peoples R China
[2] Xi An Jiao Tong Univ, Sch Med, Affiliated Guangren Hosp, Dept Gastroenterol,Xian Hosp 4, Xian 710004, Shaanxi, Peoples R China
[3] Shaanxi Prov Tumor Hosp, Dept Gen Surg 1, Xian 710068, Shaanxi, Peoples R China
[4] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Xian 710061, Shaanxi, Peoples R China
[5] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Gen Surg, 277 West Yanta Rd, Xian 710061, Shaanxi, Peoples R China
来源：
ONCOLOGY REPORTS | 2018年 / 40卷 / 06期
关键词：
long non-coding RNA; FOXD2-AS1; microRNA; hepatocellular carcinoma; miR-206; PROMOTES; CANCER; CERNA; PROGRESSION; INVASION; PATHWAY;
D O I：
10.3892/or.2018.6752
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Recently, long non-coding RNA (lncRNA) FOXD2 adjacent opposite strand RNA 1 (FOXD2-AS1) has been recognized to function as an oncogene in several human tumors, and FOXD2-AS1 dysregulation has been closely associated with carcinogenesis and tumor progression. Nevertheless, the correlation between the aberrant expression of FOXD2-AS1 and the prognosis of hepatocellular carcinoma (HCC) has not yet been elucidated. In the present study, FOXD2-AS1 was found to be overexpressed in HCC tissues, and FOXD2-AS1 overexpression resulted in significantly shortened patient survival. FOXD2-AS1 overexpression enhanced the viability and metastasis of HCC cells in vitro and in vivo, as revealed by MTT, wound healing and cell migration assays. In addition, mechanistic studies revealed that FOXD2-AS1 upregulated the expression of the miR-206 target gene annexin A2 (ANXA2) by acting as a miR-206 sponge. In summary, FOXD2-AS1 was concluded to function as an oncogene in HCC and to upregulate ANXA2 expression in part by sponging' miR-206.
引用
收藏
页码：3625 / 3634
页数：10
相关论文
共 50 条
  • [1] Long noncoding RNA FOXD2-AS1 aggravates hepatocellular carcinoma tumorigenesis by regulating the miR-206/MAP3K1 axis
    Hu, Wei
    Feng, Hui
    Xu, Xiaoyu
    Huang, Xin
    Huang, Xingyue
    Chen, Wenwei
    Hao, Lidan
    Xia, Wenfang
    CANCER MEDICINE, 2020, 9 (15): : 5620 - 5631
  • [2] Prognostic value of long non-coding RNA FOXD2-AS1 expression in patients with solid tumors
    Zhou, Lu
    Li, Zhi
    Shao, Xinye
    Yang, Bowen
    Feng, Jing
    Xu, Lu
    Teng, Yuee
    PATHOLOGY RESEARCH AND PRACTICE, 2019, 215 (09)
  • [3] The role of long non-coding RNA in hepatocellular carcinoma
    Liang, Weizheng
    Zhao, Yan
    Meng, Qingxue
    Jiang, Wenjie
    Deng, Shoulong
    Xue, Jun
    AGING-US, 2024, 16 (04): : 4052 - 4073
  • [4] RETRACTED: The long non-coding RNA-ROR promotes osteosarcoma progression by targeting miR-206 (Retracted Article)
    Fei, Dan
    Sui, Guoqing
    Lu, Yang
    Tan, Long
    Zhao Dongxu
    Zhang, Kewei
    JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2019, 23 (03) : 1865 - 1872
  • [5] Long non-coding RNA BACE1-AS plays an oncogenic role in hepatocellular carcinoma cells through miR-214-3p/APLN axis
    Tian, Qing
    Yan, Xiaodong
    Yang, Long
    Liu, Zirong
    Yuan, Zheyue
    Zhang, Yamin
    ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2021, 53 (11) : 1538 - 1546
  • [6] Downregulation of the long non-coding RNA FOXD2-AS1 inhibits cell proliferation, migration and invasion in osteosarcoma
    Zhang, Haomeng
    Lu, Yao
    Wang, Jun
    Zhang, Tian
    Dong, Chuan
    Li, Xiaoxiang
    Wang, Xinli
    Ma, Qiong
    Yang, Tongtao
    Zhou, Yong
    MOLECULAR MEDICINE REPORTS, 2019, 20 (01) : 292 - 302
  • [7] Upregulation of long non-coding RNA FOXD2-AS1 promotes progression and predicts poor prognosis in tongue squamous cell carcinoma
    Zhou, Guangming
    Huang, Zixian
    Meng, Yiyi
    Jin, Tingting
    Liang, Yancan
    Zhang, Bin
    JOURNAL OF ORAL PATHOLOGY & MEDICINE, 2020, 49 (10) : 1011 - 1018
  • [8] Role of the long non-coding RNA HOTAIR in hepatocellular carcinoma
    Wu, Liming
    Zhang, Lele
    Zheng, Shusen
    ONCOLOGY LETTERS, 2017, 14 (02) : 1233 - 1239
  • [9] Role of microRNA and Long Non-Coding RNA in Hepatocellular Carcinoma
    Gupta, Meenakshi
    Chandan, Kumari
    Sarwat, Maryam
    CURRENT PHARMACEUTICAL DESIGN, 2020, 26 (04) : 415 - 428
  • [10] Long non-coding RNA FOXD2-AS1 aggravates nasopharyngeal carcinoma carcinogenesis by modulating miR-363-5p/S100A1 pathway
    Chen, Gang
    Sun, Wenjie
    Hua, Xinying
    Zeng, Wei
    Yang, Lijing
    GENE, 2018, 645 : 76 - 84
12345