The developing immune network in human prenatal skin

被引：13
作者：
Botting, Rachel Anne [1 ]
Haniffa, Muzlifah [1 ,2 ,3 ,4 ]
机构：
[1] Newcastle Univ, Fac Med Sci, Biosci Inst, Newcastle Upon Tyne, Tyne & Wear, England
[2] Wellcome Sanger Inst, Hinxton, England
[3] Newcastle Hosp NHS Fdn Trust, Dept Dermatol, Newcastle Upon Tyne, Tyne & Wear, England
[4] Newcastle Hosp NHS Fdn Trust, NIHR Newcastle Biomed Res Ctr, Newcastle Upon Tyne, Tyne & Wear, England
来源：
IMMUNOLOGY | 2020年 / 160卷 / 02期
关键词：
haematopoiesis; immune homeostasis; regulation; suppression; skin; INNATE LYMPHOID-CELLS; REGULATORY T-CELLS; LANGERHANS CELLS; FETAL SKIN; DENDRITIC CELLS; STEADY-STATE; MAST-CELLS; STEM-CELLS; TGF-BETA; RESIDENT;
D O I：
10.1111/imm.13192
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Establishment of a well-functioning immune network in skin is crucial for its barrier function. This begins in utero alongside the structural differentiation and maturation of skin, and continues to expand and diversify across the human lifespan. The microenvironment of the developing human skin supports immune cell differentiation and has an overall anti-inflammatory profile. Immunologically inert and skewed immune populations found in developing human skin promote wound healing, and as such may play a crucial role in the structural changes occurring during skin development.
引用
收藏
页码：149 / 156
页数：8
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