An Initial Experiment With Personalized Antiplatelet Therapy The GRAVITAS Trial

被引:28
作者
Gurbel, Paul A. [1 ]
Tantry, Udaya S. [1 ]
机构
[1] Sinai Hosp, Cardiac Catheterizat Lab, Sinai Ctr Thrombosis Res, Baltimore, MD 21215 USA
来源
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | 2011年 / 305卷 / 11期
关键词
ACUTE CORONARY SYNDROMES; PLATELET INHIBITION; CLOPIDOGREL; RESISTANCE; REACTIVITY; TICAGRELOR; RESPONDERS; PRASUGREL;
D O I
10.1001/jama.2011.332
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:1136 / 1137
页数:2
相关论文
共 12 条
[1]   Adjusted clopidogrel loading doses according to vasodilator-stimulated phosphoprotein phosphorylation index decrease rate of major adverse cardiovascular events in patients with clopidogrel resistance: A multicenter randomized prospective study [J].
Bonello, Laurent ;
Camoin-Jau, Laurence ;
Arques, Stephane ;
Boyer, Christian ;
Panagides, Dimitri ;
Wittenberg, Olivier ;
Simeoni, Marie-Claude ;
Barragan, Paul ;
Dignat-George, Francoise ;
Paganelli, Franck .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2008, 51 (14) :1404-1411
[2]   Consensus and Future Directions on the Definition of High On-Treatment Platelet Reactivity to Adenosine Diphosphate [J].
Bonello, Laurent ;
Tantry, Udaya S. ;
Marcucci, Rossella ;
Blindt, Ruediger ;
Angiolillo, Dominick J. ;
Becker, Richard ;
Bhatt, Deepak L. ;
Cattaneo, Marco ;
Collet, Jean Philippe ;
Cuisset, Thomas ;
Gachet, Christian ;
Montalescot, Gilles ;
Jennings, Lisa K. ;
Kereiakes, Dean ;
Sibbing, Dirk ;
Trenk, Dietmar ;
Van Werkum, Jochem W. ;
Paganelli, Franck ;
Price, Matthew J. ;
Waksman, Ron ;
Gurbel, Paul A. .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2010, 56 (12) :919-933
[3]   Comparison of Platelet Function Tests in Predicting Clinical Outcome in Patients Undergoing Coronary Stent Implantation [J].
Breet, Nicoline J. ;
van Werkum, Jochem W. ;
Bouman, Heleen J. ;
Kelder, Johannes C. ;
Ruven, Henk J. T. ;
Bal, Egbert T. ;
Deneer, Vera H. ;
Harmsze, Ankie M. ;
van der Heyden, Jan A. S. ;
Rensing, Benno J. W. M. ;
Suttorp, Maarten J. ;
Hackeng, Christian M. ;
ten Berg, Jurrien M. .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2010, 303 (08) :754-762
[4]   Study design and rationale of a comparison of prasugrel and clopidogrel in medically managed patients with unstable angina/non-ST-segment elevation myocardial infarction: The TaRgeted platelet Inhibition to cLarify the Optimal strateGy to medicallY manage Acute Coronary Syndromes (TRILOGY ACS) trial [J].
Chin, Chee Tang ;
Roe, Matthew T. ;
Fox, Keith A. A. ;
Prabhakaran, Dorairaj ;
Marshall, Debra A. ;
Petitjean, Helene ;
Lokhnygina, Yuliya ;
Brown, Eileen ;
Armstrong, Paul W. ;
White, Harvey D. ;
Ohman, E. Magnus .
AMERICAN HEART JOURNAL, 2010, 160 (01) :16-U35
[5]   Central role of the P2Y12 receptor in platelet activation [J].
Dorsam, RT ;
Kunapuli, SP .
JOURNAL OF CLINICAL INVESTIGATION, 2004, 113 (03) :340-345
[6]   Clopidogrel for coronary stenting - Response variability, drug resistance, and the effect of pretreatment platelet reactivity [J].
Gurbel, PA ;
Bliden, KP ;
Hiatt, BL ;
O'Connor, CM .
CIRCULATION, 2003, 107 (23) :2908-2913
[7]   Platelet function monitoring in patients with coronary artery disease [J].
Gurbel, Paul A. ;
Becker, Richard C. ;
Mann, Kenneth G. ;
Steinhubl, Steven R. ;
Michelson, Alan D. .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2007, 50 (19) :1822-1834
[8]   Response to Ticagrelor in Clopidogrel Nonresponders and Responders and Effect of Switching Therapies The RESPOND Study [J].
Gurbel, Paul A. ;
Bliden, Kevin P. ;
Butler, Kathleen ;
Antonino, Mark J. ;
Wei, Cheryl ;
Teng, Renli ;
Rasmussen, Lars ;
Storey, Robert F. ;
Nielsen, Tonny ;
Eikelboom, John W. ;
Sabe-Affaki, Georges ;
Husted, Steen ;
Kereiakes, Dean J. ;
Henderson, David ;
Patel, Dharmendra V. ;
Tantry, Udaya S. .
CIRCULATION, 2010, 121 (10) :1188-1199
[9]   Standard- vs High-Dose Clopidogrel Based on Platelet Function Testing After Percutaneous Coronary Intervention The GRAVITAS Randomized Trial [J].
Price, Matthew J. ;
Berger, Peter B. ;
Teirstein, Paul S. ;
Tanguay, Jean-Francois ;
Angiolillo, Dominick J. ;
Spriggs, Douglas ;
Puri, Sanjeev ;
Robbins, Mark ;
Garratt, Kirk N. ;
Bertrand, Olivier F. ;
Stillablower, Michael E. ;
Aragon, Joseph R. ;
Kandzari, David E. ;
Stinis, Curtiss T. ;
Lee, Michael S. ;
Manoukian, Steven V. ;
Cannon, Christopher P. ;
Schork, Nicholas J. ;
Topol, Eric J. .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2011, 305 (11) :1097-1105
[10]   Intensifying Platelet Inhibition With Tirofiban in Poor Responders to Aspirin, Clopidogrel, or Both Agents Undergoing Elective Coronary Intervention Results From the Double-Blind, Prospective, Randomized Tailoring Treatment With Tirofiban in Patients Showing Resistance to Aspirin and/or Resistance to Clopidogrel Study [J].
Valgimigli, Marco ;
Campo, Gianluca ;
de Cesare, Nicoletta ;
Meliga, Emanuele ;
Vranckx, Pascal ;
Furgieri, Alessandro ;
Angiolillo, Dominick J. ;
Sabate, Manel ;
Hamon, Martial ;
Repetto, Alessandra ;
Colangelo, Salvatore ;
Brugaletta, Salvatore ;
Parrinello, Giovanni ;
Percoco, Gianfranco ;
Ferrari, Roberto .
CIRCULATION, 2009, 119 (25) :3215-3222