Sirtuins: To Be or Not To Be in Diabetic Cardiomyopathy

被引：37
作者：
Palomer, Xavier [1 ,2 ,3 ,4 ]
Aguilar-Recarte, David [1 ,2 ,3 ,4 ]
Garcia, Raquel [5 ,6 ]
Francisco Nistal, J. [6 ,7 ,8 ,9 ]
Vazquez-Carrera, Manuel [1 ,2 ,3 ,4 ]
机构：
[1] Univ Barcelona, Dept Pharmacol Toxicol & Therapeut Chem, Fac Pharm & Food Sci, Barcelona, Spain
[2] Univ Barcelona IBUB, Inst Biomed, Barcelona, Spain
[3] Inst Salud Carlos III, Spanish Biomed Res Ctr Diabet & Associated Metab, Barcelona, Spain
[4] Hosp St Joan de Deu, Pediat Res Inst, Barcelona, Spain
[5] Univ Cantabria, Fac Med, Dept Fisiol & Farmacol, Santander, Spain
[6] Inst Invest Marques de Valdecilla IDIVAL, Santander, Spain
[7] Hosp Univ Marques de Valdecilla, Serv Cirugia Cardiovasc, Santander, Spain
[8] Univ Cantabria, Fac Med, Dept Ciencias Med & Quirurg, Santander, Spain
[9] Inst Salud Carlos III, Ctr Invest Biomed Red Cardiovasc CIBERCV, Santander, Spain
来源：
TRENDS IN MOLECULAR MEDICINE | 2021年 / 27卷 / 06期
关键词：
NF-KAPPA-B; DOXORUBICIN-INDUCED CARDIOTOXICITY; ENDOPLASMIC-RETICULUM STRESS; DEPENDENT GENE-EXPRESSION; IMPROVES CARDIAC-FUNCTION; FATTY-ACID OXIDATION; INDUCED APOPTOSIS; SKELETAL-MUSCLE; AKT ACTIVATION; CELL-SURVIVAL;
D O I：
10.1016/j.molmed.2021.03.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Diabetic cardiomyopathy is the leading cause of death among people with diabetes. Despite its severity and poor prognosis, there are currently no approved specific drugs to prevent or even treat diabetic cardiomyopathy. There is a need to understand the pathogenic mechanisms underlying the development of diabetic cardiomyopathy to design new therapeutic strategies. These mechanisms are complex and intricate and include metabolic dysregulation, inflammation, oxidative stress, fibrosis, and apoptosis. Sirtuins, a group of deacetylase enzymes, play an important role in all these processes and are, therefore, potential molecular targets for treating this disease. In this review, we discuss the role of sirtuins in the heart, focusing on their contribution to the pathogenesis of diabetic cardiomyopathy and how their modulation could be therapeutically useful.
引用
收藏
页码：554 / 571
页数：18
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