LEF1 turns over a new leaf

被引：12
作者：
de Lau, W
Clevers, H [1 ]
机构：
[1] Univ Utrecht, Med Ctr, Dept Immunol, Utrecht, Netherlands
[2] Univ Utrecht, Med Ctr, Ctr Biomed Genet, Utrecht, Netherlands
来源：
NATURE GENETICS | 2001年 / 28卷 / 01期
关键词：
D O I：
10.1038/88233
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
LEF and TCF transcription factors (referred to collectively as LEF/TCFs) are pivotal players in the molecular pathology of cancer of the intestinal tract. Mutant components of the Wnt signal transduction cascade invariably lead to the inappropriate activation of LEF/TCFs in the cancer cell. A new study provides evidence for an unexpected amplification step in this cascade. The inappropriate activity of the Wnt pathway in colorectal cancer cells induces the expression of LEF1, which is normally not expressed in intestinal epithelium.
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页码：3 / 4
页数：2
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