Recent advances of chitosan nanoparticles as drug carriers

被引：544

作者：

Wang, Jun Jie ^{[1
]}

Zeng, Zhao Wu ^{[1
,2
]}

Xiao, Ren Zhong ^{[1
]}

Xie, Tian ^{[1
]}

Zhou, Guang Lin ^{[1
]}

Zhan, Xiao Ri ^{[1
]}

Wang, Shu Ling ^{[1
]}

机构：

[1] Hangzhou Normal Univ, Res Ctr Biomed & Hlth, Hangzhou 310012, Zhejiang, Peoples R China

[2] Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou, Zhejiang, Peoples R China

来源：

INTERNATIONAL JOURNAL OF NANOMEDICINE | 2011年 / 6卷

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

chitosan nanoparticle; drug delivery system; preparation; modification; application; MOLECULAR-WEIGHT; DNA NANOPARTICLES; IN-VITRO; EMULSION POLYMERIZATION; ORAL BIOAVAILABILITY; RELEASE BEHAVIOR; DELIVERY-SYSTEMS; FORMULATION; POLY(N-ISOPROPYLACRYLAMIDE); BIODISTRIBUTION;

D O I：

10.2147/IJN.S17296

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Chitosan nanoparticles are good drug carriers because of their good biocompatibility and biodegradability, and can be readily modified. As a new drug delivery system, they have attracted increasing attention for their wide applications in, for example, loading protein drugs, gene drugs, and anticancer chemical drugs, and via various routes of administration including oral, nasal, intravenous, and ocular. This paper reviews published research on chitosan nanoparticles, including its preparation methods, characteristics, modification, in vivo metabolic processes, and applications.

引用

页码：765 / 774

页数：10

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