Targeting the Wnt signaling pathway for breast cancer bone metastasis therapy

被引：3

作者：

Cui, Jingyao ^{[1
]}

Chen, Haoran ^{[1
]}

Zhang, Kaiwen ^{[1
]}

Li, Xin ^{[1
]}

机构：

[1] Sichuan Univ, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, State Key Lab Oral Dis, Chengdu 610041, Sichuan, Peoples R China

来源：

JOURNAL OF MOLECULAR MEDICINE-JMM | 2022年 / 100卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Wnt pathway; Breast cancer bone metastasis; Bone homeostasis; Bone pathology; Bone therapeutics; SMALL-MOLECULE INHIBITORS; MESENCHYMAL STEM-CELLS; E-SELECTIN ANTAGONIST; VITAMIN-D DEFICIENCY; BETA-CATENIN; IN-VIVO; POSTMENOPAUSAL WOMEN; ZOLEDRONIC ACID; OSTEOGENESIS IMPERFECTA; SCLEROSTIN ANTIBODY;

D O I：

10.1007/s00109-021-02159-y

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Osteolytic bone destruction is found in approximately 60% of advanced breast cancer patients. With the pathogenesis of bone metastasis being unclear, traditional antiresorptive therapeutic strategies might not be ideal for treatment. The Wnt pathway is a highly organized cascade involved in multiple stages of cancer bone metastasis, and Wnt-targeted therapeutic strategies have shown promise in achieving favorable outcomes. In this review, we summarize the current progress of pharmacological Wnt modulators against breast cancer bone metastasis, discuss emerging therapeutic strategies based on Wnt pathway-related targets for bone therapy, and highlight opportunities to better harness the Wnt pathway for bone metastasis therapeutics to further reveal the implications of the Wnt pathway in bone metastasis pathology and provide new ideas for the development of Wnt-based intervention strategies against breast cancer bone metastasis.

引用

页码：373 / 384

页数：12

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