Association with TP53 codon 72 polymorphism and the risk of non-Hodgkin lymphoma

被引：10

作者：

Kim, Hee Nam ^{[1
]}

Yu, Li ^{[1
]}

Kim, Nan Young ^{[1
]}

Lee, Il-Kwon ^{[1
]}

Kim, Yeo-Kyeoung ^{[2
]}

Yang, Deok-Hwan ^{[2
]}

Lee, Je-Jung ^{[2
]}

Shin, Min-Ho ^{[3
]}

Park, Kyeong-Soo ^{[4
]}

Choi, Jin-Su ^{[3
]}

Kim, Hyeoung-Joon ^{[1
,2
]}

机构：

[1] Chonnam Natl Univ, Hwasun Hosp, Genome Res Ctr Hematopoiet Dis, Jeollanamdo, South Korea

[2] Chonnam Natl Univ, Hwasun Hosp, Dept Hematol Oncol, Jeollanamdo, South Korea

[3] Chonnam Natl Univ, Sch Med, Dept Prevent Med, Kwangju, South Korea

[4] Seonam Univ, Coll Med, Dept Prevent Med, Namwon, South Korea

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 2010年 / 85卷 / 10期

关键词：

TUMOR-SUPPRESSOR GENE; LUNG-CANCER RISK; COLORECTAL-CANCER; MYELOID-LEUKEMIA; BREAST-CANCER; P53; MUTATIONS; ARG72PRO; SUSCEPTIBILITY; PROGRESSION;

D O I：

10.1002/ajh.21834

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Polymorphism of TP53 Arg72Pro is associated with many different cancers [1-4]. Few studies have investigated its role in the susceptibility to non-Hodgkin lymphoma (NHL) [5,6]. To examine the association between this polymorphism and NHL risk, we conducted a Korean large-scale, population-based case-control study (945 cases and 1,700 controls). The TP53 72 CC genotype was associated with increased risk of NHL (P=0.04) and diffuse large B-cell lymphoma (P=0.04). Our findings provide evidence that the TP53 Arg72Pro is associated with an increased risk of NHL in Korea.

引用

页码：822 / 824

页数：3

共 28 条

[1] Association of the germline TP53 R337H mutation with breast cancer in southern Brazil [J].