Glutaraldehyde cross-linked chitosan microspheres for controlled release of centchroman

被引:98
作者
Gupta, K. C. [1 ]
Jabrail, Fawzl Habeeb [1 ]
机构
[1] Indian Inst Technol, Dept Chem, Polymer Res Lab, Roorkee 247667, Uttar Pradesh, India
关键词
chitosan; deacetylation; centchroman; glutaraldehyde; microspheres;
D O I
10.1016/j.carres.2007.06.009
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Glutaraldehyde cross-linked chitosan microspheres were prepared for controlled release of centchroman, a nonsteroidal contraceptive. The cross-linked microspheres with low-molecular-weight (LMW) chitosan (260 kg mol(-1)) have shown maximum degree of swelling (287 wt %) but were found to be poor in loading and release behavior for centchroman. The microspheres with medium-molecular-weight (MMW) chitosan (1134 kg mol(-1)) have shown 250 wt % degree of swelling and 37.5 wt % loading of centchroman, but microspheres with high-molecular-weight (HMW) chitosan (2224 kg mol(-1)) have shown a low degree of swelling (150 wt %) and centchroman loading (30 wt %). The microspheres with MMW chitosan have released 82 wt % of loaded centchroman in a controlled release manner within a period of 70 h in comparison to low- (260 kg mol(-1)) and high-MW (2224 kg mol(-1)) chitosan microspheres. The chitosan microspheres with 62 wt % degree of deacetylation (DDA) were more efficient in the controlled release of centchroman in comparison to chitosan microspheres with low (48 wt %) and high-DDA (75 wt %). The fractional release of centchroman (M-t/M-infinity) from chitosan microspheres was used to predict the mechanism of drug release and to determine the diffusion constant (D) of centchroman. (C) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码:2244 / 2252
页数:9
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