Neonatal Fc Receptor: From Immunity to Therapeutics

被引：188
作者：
Kuo, Timothy T. [1 ]
Baker, Kristi [1 ]
Yoshida, Masaru [2 ,3 ]
Qiao, Shuo-Wang [4 ]
Aveson, Victoria G. [1 ]
Lencer, Wayne I. [5 ]
Blumberg, Richard S. [1 ]
机构：
[1] Harvard Univ, Brigham & Womens Hosp, Div Gastroenterol, Dept Med,Med Sch, Boston, MA 02115 USA
[2] Kobe Univ, Grad Sch Med, Dept Gastroenterol, Chuo Ku, Kobe, Hyogo 6500017, Japan
[3] Kobe Univ, Grad Sch Med, Integrated Ctr Mass Spectrometry, Chuo Ku, Kobe, Hyogo 6500017, Japan
[4] Univ Oslo, Rikshosp, Inst Immunol, N-0027 Oslo, Norway
[5] Harvard Univ, Div Gastroenterol, Childrens Hosp, Harvard Digest Dis Ctr,Med Sch, Boston, MA 02115 USA
来源：
JOURNAL OF CLINICAL IMMUNOLOGY | 2010年 / 30卷 / 06期
关键词：
FcRn; Fcgrt; Brambell; IgG; Fc; albumin; transcytosis; transport; recycling; I-RELATED RECEPTOR; IMMUNOGLOBULIN-G TRANSPORT; PH-DEPENDENT BINDING; IGG TRANSPORT; FUNCTIONAL EXPRESSION; MAMMARY-GLAND; MEDIATED TRANSCYTOSIS; EPITHELIAL-CELLS; ALBUMIN-BINDING; FUSION PROTEIN;
D O I：
10.1007/s10875-010-9468-4
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The neonatal Fc receptor (FcRn), also known as the Brambell receptor and encoded by Fcgrt, is a MHC class I like molecule that functions to protect IgG and albumin from catabolism, mediates transport of IgG across epithelial cells, and is involved in antigen presentation by professional antigen presenting cells. Its function is evident in early life in the transport of IgG from mother to fetus and neonate for passive immunity and later in the development of adaptive immunity and other functions throughout life. The unique ability of this receptor to prolong the half-life of IgG and albumin has guided engineering of novel therapeutics. Here, we aim to summarize the basic understanding of FcRn biology, its functions in various organs, and the therapeutic design of antibody- and albumin-based therapeutics in light of their interactions with FcRn.
引用
收藏
页码：777 / 789
页数：13
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