Decarboxylative acylation of arenes with mandelic acid derivatives via palladium-catalyzed oxidative sp2 C-H activation

被引：18

作者：

Liu, Xia ^{[1
]}

Yi, Ze ^{[1
]}

Wang, Jianhui ^{[1
]}

Liu, Guiyan ^{[2
]}

机构：

[1] Tianjin Univ, Coll Sci, Dept Chem, Tianjin 300072, Peoples R China

[2] Tianjin Normal Univ, Tianjin Key Lab Struct & Performance Funct Mol, Key Lab Inorgan Organ Hybrid Funct Mat Chem, Minist Educ,Coll Chem, Tianjin 300387, Peoples R China

来源：

RSC ADVANCES | 2015年 / 5卷 / 14期

关键词：

ALPHA-OXOCARBOXYLIC ACIDS; BOND FORMATION; DIRECT ARYLATION; ROOM-TEMPERATURE; BENZOIC-ACIDS; ALDEHYDES; CLEAVAGE; 2-ARYLPYRIDINES; INTERMEDIATE; COMPLEXES;

D O I：

10.1039/c4ra14107e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient palladium catalyzed decarboxylative acylation of arenes with mandelic acid derivatives via oxidative sp(2) C-H activation in the presence of tert-butyl hydroperoxide has been developed. The acylation reaction is assisted by a pyridine directing group. The starting materials are inexpensive and readily available. This method provides an economical and convenient way to synthesize aryl ketones.

引用

页码：10641 / 10646

页数：6

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