Incidence of and risk factors for pancreatic cancer in chronic pancreatitis: A cohort of 1656 patients

被引：77

作者：

Hao, Lu ^{[1
]}

Zeng, Xiang-Peng ^{[1
]}

Xin, Lei ^{[1
,2
]}

Wang, Dan ^{[1
]}

Pan, Jun ^{[1
]}

Bi, Ya-Wei ^{[1
]}

Ji, Jun-Tao ^{[2
]}

Du, Ting-Ting ^{[1
]}

Lin, Jin-Huan ^{[1
]}

Zhang, Di ^{[1
]}

Ye, Bo ^{[3
]}

Zou, Wen-Bin ^{[1
]}

Chen, Hui ^{[1
,2
]}

Xie, Ting ^{[4
]}

Li, Bai-Rong ^{[5
]}

Zheng, Zhao-Hong ^{[6
]}

Wang, Teng ^{[1
,2
]}

Guo, Hong-Lei ^{[1
]}

Liao, Zhuan ^{[1
,2
]}

Li, Zhao-Shen ^{[1
,2
]}

Hu, Liang-Hao ^{[1
,2
]}

机构：

[1] Second Mil Med Univ, Changhai Hosp, Dept Gastroenterol, Shanghai, Peoples R China

[2] Second Mil Med Univ, Changhai Hosp, Digest Endoscopy Ctr, Shanghai, Peoples R China

[3] Jinling Hosp, Dept Surg, Nanjing, Jiangsu, Peoples R China

[4] Southeast Univ, Zhongda Hosp, Dept Gastroenterol, Nanjing, Jiangsu, Peoples R China

[5] Air Force Gen Hosp, Dept Gastroenterol, Beijing, Peoples R China

[6] Jiangdu Hosp, Dept Tradit Chinese Med, Yangzhou, Jiangsu, Peoples R China

来源：

DIGESTIVE AND LIVER DISEASE | 2017年 / 49卷 / 11期

基金：

中国国家自然科学基金;

关键词：

Chronic pancreatitis; Pancreatic cancer; Risk factors; SHOCK-WAVE LITHOTRIPSY; CHINESE PATIENTS; HEREDITARY PANCREATITIS; ENDOSCOPIC TREATMENT; DIABETES-MELLITUS; NCCN GUIDELINES; MEDICAL HISTORY; DIAGNOSIS; CARCINOMA; ADENOCARCINOMA;

D O I：

10.1016/j.dld.2017.07.001

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background: Risk of pancreatic cancer may increase in chronic pancreatitis patients. Aims: This study aimed to identify the incidence of and risk factors for pancreatic cancer in chronic pancreatitis patients. Methods: Chronic pancreatitis patients admitted to our center from January 2000 to December 2013 were enrolled. Cumulative rates of pancreatic cancer and survival rates were calculated. The standardized incidence ratio was calculated based on the pancreatic cancer incidence in general population of China. Risk factors for pancreatic cancer were identified. Results: In a total of 1656 patients, the median follow-up duration was 8.0 years. Pancreatic cancer was detected in 21 patients (1.3%). The expected number of cases of pancreatic cancer was 1.039, yielding a standardized incidence ratio of 20.22. The standardized incidence ratios for patients with a >60 pack-year smoking history were much higher (145.82). Two risk factors for pancreatic cancer were identified: age at the onset of chronic pancreatitis (hazard ratio, 1.05) and a >60 pack-year smoking history (hazard ratio, 11.83). Conclusion: The risk of pancreatic cancer is markedly increased in chronic pancreatitis patients compared with the general population, especially in patients with an older age at onset and a >60 pack-year smoking history. The high-risk populations were suggested to be followed up closely. (C) 2017 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

引用

页码：1249 / 1256

页数：8

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