The role of optimal control in assessing the most cost-effective implementation of a vaccination programme: HPV as a case study

被引：30

作者：

Brown, V. L. ^{[1
]}

White, K. A. Jane ^{[1
]}

机构：

[1] Univ Bath, Ctr Math Biol, Bath BA2 7AY, Avon, England

来源：

MATHEMATICAL BIOSCIENCES | 2011年 / 231卷 / 02期

基金：

英国工程与自然科学研究理事会;

关键词：

Mathematical model; Public health policy; Sexually transmitted infection; HUMAN-PAPILLOMAVIRUS VACCINATION; CERVICAL-CANCER; PUBLIC-HEALTH; INFECTION; EPIDEMICS;

D O I：

10.1016/j.mbs.2011.02.009

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Vaccination against the human papillomavirus (HPV) is a recent development in the UK. This paper uses an optimal control model to explore how best to target vaccination. We find that the vaccination of sexually active individuals has a greater impact on disease control than the vaccination of sexually non-active individuals. Extending the model to include male vaccination, we find that including males in a vaccination strategy is cost-effective. We compare the optimal control solution to that from a constant control model and show that the optimal control model is more efficient at forcing the system to a disease-controlled steady state. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：126 / 134

页数：9

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