Histamine-induced internalization of substance P receptors in myoepithelial cells of the guinea pig nasal glands

Numerous substance P (SP) immunoreactive nerve fibers were located around submucosal glands in the guinea pig nasal mucosa. Since these SP positive nerve fibers were also positive for vasoactive intestinal polypeptide, and to a lessor extent for neuropeptide Y, they were presumed to be parasympathetic fibers. SP receptor positive structures were observed exclusively on the membrane of myoepithelial cells in normal nasal mucose, suggesting that myoepithelial cells are targets of SP positive fibers. SP receptor-like immunoreactivity was observed associated with intracellular organella of myoepithelial cells 5 min after intranasal histamine challenge, which may indicate the molecular basis for histamine-induced nasal discharge. (C) 1998 Elsevier Science Inc.