Pre- and early postoperative GFAP serum levels in glioma and brain metastases

被引:16
作者
Baumgarten, Peter [1 ]
Quick-Weller, Johanna [1 ]
Gessler, Florian [1 ]
Wagner, Marlies [2 ]
Tichy, Julia [3 ]
Forster, Marie-Therese [1 ]
Foerch, Christian [3 ]
Seifert, Volker [1 ]
Mittelbronn, Michel [4 ,5 ,6 ,7 ,8 ,9 ,10 ]
Senft, Christian [1 ]
机构
[1] Goethe Univ Frankfurt, Univ Hosp, Dept Neurosurg, D-60528 Frankfurt, Germany
[2] Goethe Univ Frankfurt, Inst Neuroradiol, Frankfurt, Germany
[3] Goethe Univ Frankfurt, Dept Neurol, Frankfurt, Germany
[4] Goethe Univ Frankfurt, Edinger Inst, Frankfurt, Germany
[5] German Canc Consortium DKTK, Heidelberg, Germany
[6] German Canc Res Ctr, Heidelberg, Germany
[7] Univ Luxembourg, Luxembourg Ctr Syst Biomed LCSB, Esch Sur Alzette, Luxembourg
[8] Lab Natl Sante LNS, Dudelange, Luxembourg
[9] Luxembourg Inst Hlth LIH, Dept Oncol, NORLUX Neurooncol Lab, Luxembourg, Luxembourg
[10] Luxembourg Ctr Neuropathol LCNP, Dudelange, Luxembourg
关键词
GFAP; Glioblastoma; Brain metastasis; Resection; Biomarker; FIBRILLARY ACIDIC PROTEIN; PROSTATE-SPECIFIC ANTIGEN; HIGH-GRADE GLIOMAS; SUPRAMARGINAL RESECTION; CEREBRAL METASTASES; DIAGNOSTIC MARKER; NERVOUS-SYSTEM; TUMOR VOLUME; GLIOBLASTOMA; PROGRESSION;
D O I
10.1007/s11060-018-2898-1
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
SubjectTo date there is no established tumor marker for the clinical follow-up of glioblastoma, WHO grade IV, (GBM) which constitutes the most frequent and malignant primary brain tumor. However, since there is promising data that the serum glial fibrillary acidic protein (sGFAP) may serve as a biomarker for glial brain tumors, this prospective study aimed at evaluating the diagnostic relevance of perioperative changes in sGFAP levels for the assessment of residual glial tumor tissue in patients undergoing surgery of intracerebral tumors.MethodsSerum GFAP was measured using an electrochemiluminometric immunoassay (ElecsysR GFAP prototype test, Roche Diagnostics, Penzberg/Germany) in 32 prospectively recruited patients between September 2009 and August 2010. Twenty-five were diagnosed with glioma and seven with brain metastases (BM). We assessed sGFAP levels prior to and at different time points during the early postoperative phase until patient discharge.ResultsThere were only significant differences in the pre-operative sGFAP levels of patients with gliomas compared to BM (0.18 vs. 0.08 mu g/l; p=0.0198, Welch's t-Test). Even though there was an increase of sGFAP after surgery, there were no significant differences between glioma and BM patients at any other time point. Peak sGFAP levels where reached on postoperative day 1 followed by a slight decrease, but not reaching pre-operative levels until postop day 7. There was no significant correlation between postoperative glioma tumor volume and sGFAP levels in univariate analyses.ConclusionAccording to our data sGFAP does not appear to be suitable to detect residual glioma tissue in the acute postoperative phase.
引用
收藏
页码:541 / 546
页数:6
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