Rh(III)-Catalyzed Selective C8-H Acylmethylation of Quinoline N-Oxides

被引：71

作者：

You, Chang ^{[1
]}

Pi, Chao ^{[1
]}

Wu, Yangjie ^{[1
]}

Cui, Xiuling ^{[1
]}

机构：

[1] Zhengzhou Univ, Dept Chem, Henan Key Lab Chem Biol & Organ Chem, Key Lab Appl Chem Henan Univ, Zhengzhou 450052, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2018年 / 360卷 / 21期

关键词：

C8-H bond activation; acylmethylation; quninoline N-oxide; rhodium-catalyzed; C-H ACTIVATION; RELAY CARBENOID FUNCTIONALIZATION; ASYMMETRIC-SYNTHESIS; SULFOXONIUM YLIDES; C-8; POSITION; BONDS; ALKYLATION; METAL; SULFONYLATION; ALLYLATION;

D O I：

10.1002/adsc.201800659

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A highly efficient Rh-catalyzed regioselective C8-H acylmethylation of quinoline N-oxides with sulfoxonium ylides using N-oxide as the directing group under air atmosphere has been developed. This transformation has the generality of a broad scope of substrates, avoids external oxidants, and provides an efficient protocol to C8-H acylmethylated quinolines.

引用

页码：4068 / 4072

页数：5

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