PP2A-B55: substrates and regulators in the control of cellular functions

被引：30

作者：

Amin, Priya ^{[1
]}

Awal, Sushil ^{[1
]}

Vigneron, Suzanne ^{[1
]}

Roque, Sylvain ^{[1
]}

Mechali, Francisca ^{[1
]}

Labbe, Jean Claude ^{[1
]}

Lorca, Thierry ^{[1
]}

Castro, Anna ^{[1
]}

机构：

[1] Univ Montpellier, Ctr Rech Biol Cellulaire Montpellier CRBM, CNRS UMR 5237, 1919 Route Mende, F-34293 Montpellier 5, France

来源：

ONCOGENE | 2022年 / 41卷 / 01期

关键词：

PROTEIN PHOSPHATASE 2A; GREATWALL KINASE; TUMOR-SUPPRESSOR; SUBUNIT INTERACTION; MITOTIC EXIT; T-ANTIGEN; PHOSPHORYLATION; DEPHOSPHORYLATION; CANCER; B55-ALPHA;

D O I：

10.1038/s41388-021-02068-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

PP2A is a major serine/threonine phosphatase class involved in the regulation of cell signaling through the removal of protein phosphorylation. This class of phosphatases is comprised of different heterotrimeric complexes displaying distinct substrate specificities. The present review will focus on one specific heterocomplex, the phosphatase PP2A-B55. Herein, we will report the direct substrates of this phosphatase identified to date, and its impact on different cell signaling cascades. We will additionally describe its negative regulation by its inhibitors Arpp19 and ENSA and their upstream kinase Greatwall. Finally, we will describe the essential molecular features defining PP2A-B55 substrate specificity that confer the correct temporal pattern of substrate dephosphorylation. The main objective of this review is to provide the reader with a unique source compiling all the knowledge of this particular holoenzyme that has evolved as a key enzyme for cell homeostasis and cancer development.

引用

页码：1 / 14

页数：14

共 117 条

[11] I1PP2A affects Tau phosphorylation via association with the catalytic subunit of protein phosphatase 2A [J].

Chen, She ;

Li, Bin ;

Grundke-Iqbal, Inge ;

Iqbal, Khalid .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (16) :10513-10521

[12] Evaluation of PPP2R2A as a prostate cancer susceptibility gene: a comprehensive germline and somatic study [J].

Cheng, Yu ;

Liu, Wennuan ;

Kim, Seong-Tae ;

Sun, Jishan ;

Lu, Lingyi ;

Sun, Jielin ;

Zheng, Siqun Lilly ;

Isaacs, William B. ;

Xu, Jianfeng .

CANCER GENETICS, 2011, 204 (07) :375-381

[13] Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme [J].

Cho, Uhn Soo ;

Xu, Wenqing .

NATURE, 2007, 445 (7123) :53-57

[14] A PP2A-B55 recognition signal controls substrate dephosphorylation kinetics during mitotic exit [J].

Cundell, Michael J. ;

Hutter, Lukas H. ;

Bastos, Ricardo Nunes ;

Poser, Elena ;

Holder, James ;

Mohammed, Shabaz ;

Novak, Bela ;

Barr, Francis A. .

JOURNAL OF CELL BIOLOGY, 2016, 214 (05) :539-554

[15] The BEG (PP2A-B55/ENSA/Greatwall) Pathway Ensures Cytokinesis follows Chromosome Separation [J].

Cundell, Michael J. ;

Bastos, Ricardo Nunes ;

Zhang, Tongli ;

Holder, James ;

Gruneberg, Ulrike ;

Novak, Bela ;

Barr, Francis A. .

MOLECULAR CELL, 2013, 52 (03) :393-405

[16] The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups [J].

Curtis, Christina ;

Shah, Sohrab P. ;

Chin, Suet-Feung ;

Turashvili, Gulisa ;

Rueda, Oscar M. ;

Dunning, Mark J. ;

Speed, Doug ;

Lynch, Andy G. ;

Samarajiwa, Shamith ;

Yuan, Yinyin ;

Graef, Stefan ;

Ha, Gavin ;

Haffari, Gholamreza ;

Bashashati, Ali ;

Russell, Roslin ;

McKinney, Steven ;

Langerod, Anita ;

Green, Andrew ;

Provenzano, Elena ;

Wishart, Gordon ;

Pinder, Sarah ;

Watson, Peter ;

Markowetz, Florian ;

Murphy, Leigh ;

Ellis, Ian ;

Purushotham, Arnie ;

Borresen-Dale, Anne-Lise ;

Brenton, James D. ;

Tavare, Simon ;

Caldas, Carlos ;

Aparicio, Samuel .

NATURE, 2012, 486 (7403) :346-352

[17] The mTOR and PP2A Pathways Regulate PHD2 Phosphorylation to Fine-Tune HIF1α Levels and Colorectal Cancer Cell Survival under Hypoxia [J].

Di Conza, Giusy ;

Cafarello, Sarah Trusso ;

Loroch, Stefan ;

Mennerich, Daniela ;

Deschoemaeker, Sofie ;

Di Matteo, Mario ;

Ehling, Manuel ;

Gevaert, Kris ;

Prenen, Hans ;

Zahedi, Rene Peiman ;

Sickmann, Albert ;

Kietzmann, Thomas ;

Moretti, Fabiola ;

Mazzone, Massimiliano .

CELL REPORTS, 2017, 18 (07) :1699-1712

[18] Polyoma virus middle T antigen and its role in identifying cancer-related molecules [J].

Dilworth, SM .

NATURE REVIEWS CANCER, 2002, 2 (12) :951-956

[19] Loss of the Greatwall Kinase Weakens the Spindle Assembly Checkpoint [J].

Diril, M. Kasim ;

Bisteau, Xavier ;

Kitagawa, Mayumi ;

Caldez, Matias J. ;

Wee, Sheena ;

Gunaratne, Jayantha ;

Lee, Sang Hyun ;

Kaldis, Philipp .

PLOS GENETICS, 2016, 12 (09)

[20] Phosphorylation of ARPP19 by protein kinase A prevents meiosis resumption in Xenopus oocytes [J].

Dupre, Aude ;

Daldello, Enrico M. ;

Nairn, Angus C. ;

Jessus, Catherine ;

Haccard, Olivier .

NATURE COMMUNICATIONS, 2014, 5

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