Starving for survival-how catabolic metabolism fuels immune function

被引：12
作者：
Balmer, Maria L. [1 ]
Hess, Christoph [1 ]
机构：
[1] Univ Basel, Dept Biomed, Immunobiol, CH-4031 Basel, Switzerland
来源：
CURRENT OPINION IN IMMUNOLOGY | 2017年 / 46卷
基金：
瑞士国家科学基金会;
关键词：
CHAIN FATTY-ACIDS; T-CELLS; KETONE-BODIES; REGULATORY T; LIPID RAFTS; GLUCOSE; LYMPHOCYTES; ACTIVATION; GLUTAMINE; PROTECTS;
D O I：
10.1016/j.coi.2017.03.009
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Infections disturb homeostasis and often induce a switch to catabolic organismal metabolism. During catabolism, increased systemic availability of glucose, fatty acids and ketone bodies is observed, and recent evidence indicates that these metabolites might serve an immunomodulatory function. However, whereas our understanding of direct pathogen recognition by the host immune system is quite detailed, much less is known about the immunobiology of the metabolic host response to infection. In this review article we briefly discuss how pathogens induce 'dys-homeostasis' systemically, locally, and within cells, and provide examples of how such changes can shape immune-functionality during the course of an infection.
引用
收藏
页码：8 / 13
页数：6
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