The Characteristics of New Semi-Quantitative Method for Diagnosing Proteinuria by Using Random Urine Samples

被引:11
作者
Lin, Cheng-Jui [1 ,2 ]
Chen, Han-Hsiang [1 ,2 ]
Pan, Chi-Feng [1 ,2 ]
Hsieh, Wen-Shyang [3 ]
Ho, Hsin-Tsung [2 ]
Wu, Chih-Jen [1 ,2 ,4 ]
机构
[1] Mackay Mem Hosp, Div Nephrol, Dept Internal Med, Taipei 104, Taiwan
[2] Nursing & Management Coll, Mackay Med, Taipei, Taiwan
[3] Mackay Mem Hosp, Dept Lab Med, Taipei 104, Taiwan
[4] Taipei Med Univ, Grad Inst Med Sci, Taipei, Taiwan
关键词
chronic kidney disease; microalbuminuria; proteinuria; CHRONIC KIDNEY-DISEASE; CARDIOVASCULAR-DISEASE; RISK; MICROALBUMINURIA; CREATININE; ALBUMINURIA; NEPHROPATHY; PREVALENCE; RATIOS;
D O I
10.1002/jcla.20376
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
We assessed the characteristics of the new semi-quantitative test paper (Clinitek ATLAS Pro(12)) using random urine samples. Three hundred urine samples were analyzed using eitherthe new test paper, conventional dipsticks, quantitative (P/C ratio), or immunological quantitative methods (A/C ratio). Our study showed that the new test paper is highly sensitive and specific for the detection of urinary protein. The new test paper also detected the urine protein more accurately than the conventional test and has a lower false-positive rate. In addition, the new test paper detected 14 of the 300 patients (4.7%) as dilute urine samples needing reassessment. Seventeen of the 300 samples tested were negative with conventional dipsticks but positive with the new test paper. The new semi-quantitative test paper not only has higher sensitivity than the conventional dipstick method, but also has potential to detect dilute samples. J. Clin. Lab. Anal. 25:14-19, 2011. (C) 2011 Wiley-Liss, Inc.
引用
收藏
页码:14 / 19
页数:6
相关论文
共 22 条
[1]   Microalbuminuria screening by reagent strip predicts cardiovascular risk in hypertension [J].
Agrawal, B ;
Berger, A ;
Wolf, K ;
Luft, FC .
JOURNAL OF HYPERTENSION, 1996, 14 (02) :223-228
[2]  
[Anonymous], 1886, physiol. Chem., DOI DOI 10.1515/BCHM1.1886.10.5.391
[3]   Screening for proteinuria in US adults - A cost-effectiveness analysis [J].
Boulware, LE ;
Jaar, BG ;
Tarver-Carr, ME ;
Brancati, FL ;
Powe, NR .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 290 (23) :3101-3114
[4]   Prevalence of chronic kidney disease in the United States [J].
Coresh, Josef ;
Selvin, Elizabeth ;
Stevens, Lesley A. ;
Manzi, Jane ;
Kusek, John W. ;
Eggers, Paul ;
Van Lente, Frederick ;
Levey, Andrew S. .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2007, 298 (17) :2038-2047
[5]   Chronic kidney disease - The promise and the perils [J].
Couser, William G. .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2007, 18 (11) :2803-2805
[6]  
Croal B., 2003, POINT CARE, V2, P144
[7]   Cardiovascular disease and mortality in a community-based cohort with mild renal insufficiency [J].
Culleton, BF ;
Larson, MG ;
Wilson, PWF ;
Evans, JC ;
Parfrey, PS ;
Levy, D .
KIDNEY INTERNATIONAL, 1999, 56 (06) :2214-2219
[8]   Screening for microalbuminuria in the general population: a tool to detect subjects at risk for progressive renal failure in an early phase? [J].
de Jong, PE ;
Hillege, HL ;
Pinto-Sietsma, SJ ;
de Zeeuw, D .
NEPHROLOGY DIALYSIS TRANSPLANTATION, 2003, 18 (01) :10-13
[9]   Proteinuria, a target for renoprotection in patients with type 2 diabetic nephropathy: Lessons from RENAAL [J].
de Zeeuw, D ;
Remuzzi, G ;
Parving, HH ;
Keane, WF ;
Zhang, ZX ;
Shahinfar, S ;
Snapinn, S ;
Cooper, MF ;
Mitch, WE ;
Brenner, BM .
KIDNEY INTERNATIONAL, 2004, 65 (06) :2309-2320
[10]   Albuminuria and risk of cardiovascular events, death, and heart failure in diabetic and nondiabetic individuals [J].
Gerstein, HC ;
Mann, JFE ;
Yi, QL ;
Zinman, B ;
Dinneen, SF ;
Hoogwerf, B ;
Hallé, JP ;
Young, J ;
Rashkow, A ;
Joyce, C ;
Nawaz, S ;
Yusuf, S .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 286 (04) :421-426