Extrahepatic manifestations related to hepatitis E virus infection and their triggering mechanisms

被引：47

作者：

Wu, Jian ^{[1
,2
]}

Xiang, Ze ^{[3
]}

Zhu, Chunxia ^{[1
]}

Yao, Yiwen ^{[4
]}

Bortolanza, Mariza ^{[4
]}

Cao, Hongcui ^{[1
,5
]}

Li, Lanjuan ^{[1
]}

机构：

[1] Zhejiang Univ, Affiliated Hosp 1, State Key Lab Diag & Treatment Infect Dis, Natl Clin Res Ctr Infect Dis,Sch Med, 79 Qingchun Rd, Hangzhou 310003, Peoples R China

[2] Nanjing Med Univ, Affiliated Suzhou Hosp Nanjing Med Univ, Suzhou Municipal Hosp, Gusu Sch,Dept Clin Lab, 242 Guangji Rd, Suzhou 215008, Peoples R China

[3] Zhejiang Univ Sch Med, Hangzhou 310058, Peoples R China

[4] Saarland Univ Hosp, Dept Internal Med Pulmonol 5, Resp Intens Care Med, Allergol, D-66424 Homburg, Germany

[5] Zhejiang Prov Key Lab Diag & Treatment Aging & Ph, 79 Qingchun Rd, Hangzhou 310003, Peoples R China

来源：

JOURNAL OF INFECTION | 2021年 / 83卷 / 03期

关键词：

Hepatitis E virus; Extrahepatic manifestations; Genotypes; Triggering mechanism; NONTRAUMATIC NEUROLOGICAL INJURY; ACUTE VIRAL-HEPATITIS; NON-B HEPATITIS; ACUTE-PANCREATITIS; NON-A; HEMOLYTIC-ANEMIA; RENAL-FAILURE; ASSOCIATION; PATIENT; HEV;

D O I：

10.1016/j.jinf.2021.07.021

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Hepatitis E virus (HEV) infection has many extrahepatic manifestations as well as liver symptoms. Multiple studies have shown that HEV infection has symptoms related to the nervous system, kidneys, cryoglobulinemia, hematological system, reproductive system, autoimmunity and pancreas. Hence, HEV infection should be considered as a systemic disease, rather than solely a liver disease. The extrahepatic manifestations induced by different genotypes of HEV vary. The severity of these diseases does not necessarily correlate with the severity of HEV infection, and even asymptomatic HEV infection may trigger and cause systemic diseases. Patients with systemic manifestations of HEV infection should have priority for antiviral therapy, which could alleviate or improve the extrahepatic manifestations related to HEV infection. However, the extrahepatic manifestations caused by different genotypes of HEV and their corresponding mechanisms have not been clearly identified. This review discusses the extrahepatic manifestations related to HEV infection and their triggering mechanisms. (C) 2021 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

引用

页码：298 / 305

页数：8

共 107 条

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