Hypoxia, Hypoxia-inducible Factor-1α, and Innate Antileishmanial Immune Responses

被引：19

作者：

Schatz, Valentin ^{[1
]}

Neubert, Patrick ^{[1
]}

Rieger, Franz ^{[1
]}

Jantsch, Jonathan ^{[1
]}

机构：

[1] Univ Regensburg, Univ Hosp Regensburg, Inst Clin Microbiol & Hyg, Regensburg, Germany

来源：

FRONTIERS IN IMMUNOLOGY | 2018年 / 9卷

关键词：

hypoxia-inducible factor 1; leishmaniasis; macrophages; oxygen; Nos2; hypoxia; NITRIC-OXIDE SYNTHASE; NF-KAPPA-B; MOUSE PERITONEAL-MACROPHAGES; LEISHMANIA-MAJOR INFECTION; FACTOR; 1-ALPHA; CUTANEOUS LEISHMANIASIS; DEPENDENT REGULATION; REACTIVE NITROGEN; HOST MACROPHAGES; INTERFERON-GAMMA;

D O I：

10.3389/fimmu.2018.00216

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Low oxygen environments and accumulation of hypoxia-inducible factors (HIFs) are features of infected and inflamed tissues. Here, we summarize our current knowledge on oxygen levels found in Leishmania-infected tissues and discuss which mechanisms potentially contribute to local tissue oxygenation in leishmanial lesions. Moreover, we review the role of hypoxia and HIF-1 on innate antileishmanial immune responses.

引用

页数：8

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